To compare the effect of two drugs clonidine and dexmedetomidine in keeping blood pressure stable in patients having gallbladder removal surgery by laparoscopic method during general anaesthesia.

A randomised interventional comparative study to evaluate the efficacy of IV clonidine versus IV dexmedetomidine for attenuating hemodynamic stress response during laparoscopic cholecystectomy under general anaesthesia at S.M.S. Medical College, Jaipur. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112131

Enrollment

Registered

2026-06-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: General Anaesthesia in elective laparoscopic cholecystectomy: To evaluate the efficacy of IV clonidine 1mcg/kg diluted in 15ml normal saline administered over 10 mins versus IV dexmedet

completed 5 minutes before induction for attenuating hemodynamic stress response during laparoscopic cholecystectomy under general anaesthesia. Frequency - Single. Route of administration - Intravenou

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective laparoscopic cholecystectomy under General Anesthesia requiring endotracheal intubation. 2. Patients consenting to participate 3. Patients having American Society of Anesthesiologist (ASA) physical status I and II. 4. Patients having BMI between 18.5-29.9 kg/m2

Exclusion criteria

Exclusion criteria: 1. Patients with uncompensated cardiovascular pulmonary, neurological, hepatorenal, endocrine disorders. 2. Patients with known history of hypertension. 3. Pregnant or lactating women. 4. Patients with anticipated difficult airway 5. Known allergy to study drugs

Design outcomes

Secondary

Measure	Time frame
1. Mean heart rate (bpm) 2. Systolic blood pressure (mm Hg) 3. Diastolic blood pressure (mm Hg) 4. Rate pressure product (bpm mmHg) 5. Oxygen saturation (%)Timepoint: After study drug infusion, after intubation, 1min, 3min, 5min, 7min, just before pneumoperitoneum, just after pneumoperitoneum, 10min, 20min, 30min, 40min, 50min, 60min and end of surgery.;1. Incidence of bradycardia 2. Incidence of hypotensionTimepoint: After study drug infusion, after intubation, 1min, 3min, 5min, 7min, just before pneumoperitoneum, just after pneumoperitoneum, 10min, 20min, 30min, 40min, 50min, 60min and end of surgery.	—

Measure

Time frame

1. Mean heart rate (bpm) 2. Systolic blood pressure (mm Hg) 3. Diastolic blood pressure (mm Hg) 4. Rate pressure product (bpm mmHg) 5. Oxygen saturation (%)Timepoint: After study drug infusion, after intubation, 1min, 3min, 5min, 7min, just before pneumoperitoneum, just after pneumoperitoneum, 10min, 20min, 30min, 40min, 50min, 60min and end of surgery.;1. Incidence of bradycardia 2. Incidence of hypotensionTimepoint: After study drug infusion, after intubation, 1min, 3min, 5min, 7min, just before pneumoperitoneum, just after pneumoperitoneum, 10min, 20min, 30min, 40min, 50min, 60min and end of surgery.

—

Primary

Measure	Time frame
Mean arterial pressure (mm Hg)Timepoint: After study drug infusion, after intubation, 1min, 3min, 5min, 7min, just before pneumoperitoneum, just after pneumoperitoneum, 10min, 20min, 30min, 40min, 50min, 60min and end of surgery.	—

Countries

India

Contacts

Public ContactDr Avantika Gupta

Sawai Man Singh Medical College and Attached Hospital

poonamkalra24@gmail.com9413416787

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026