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Comparison of Two Bone Graft Materials Used with Platelet-Rich Fibrin for Treating Bone Loss Around Teeth in Patients with Gum Disease

Comparative Clinical and Radiographic Evaluation of Autologous Advanced Platelet Rich Fibrin (A-PRF+) with Hydroxyapatite alloplastic bone graft (B-OstIN HA) and Autologous Advanced Platelet Rich Fibrin (A-PRF +) with Xenogeneic De Mineralized Bone Matrix (ColoCast) in the Treatment of Intrabony Defects in Chronic Periodontitis Patients A Randomized Clinical Trial - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112118
Enrollment
44
Registered
2026-06-08
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Advanced Platelet Rich Fibrin (A-PRF+) and Hydroxyapatite bone graft: Autologous Advanced Platelet Rich Fibrin (A-PRF+) used in combination with Hydroxyapatite alloplastic bone graft (B

Sponsors

Dr Nandana S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients with chronic periodontitis 2) Patients who are non smokers or do not consume tobacco in any other form 3) Patients in good systemic health with no contraindication to periodontal surgery 4) Patients having pocket depths greater than 5mm, intraosseous defects greater than 3mm and with radiographic evidence of vertical or angular bone loss in the affected sites

Exclusion criteria

Exclusion criteria: 1) One-walled osseous defects. 2) Patients suffering from any systemic diseases or with a compromised immune system. 3) Patients who had received any type of periodontal therapy for the past 6 months. 4) Patients taking immunosuppressant drugs like corticosteroids. 5) Patients with a known history of allergy to Doxycycline or Chlorhexidine or any other medicine used in the study. 6) Patients showing unacceptable oral hygiene compliance during / after Phase I periodontal therapy. 7) Patients taking any drug known to cause gingival enlargement. 8) Pregnant and/or lactating mothers.

Design outcomes

Primary

MeasureTime frame
1) Plaque Index (P.I) Tureskey-Gilmore-Glickman Modification of Quigley Hein) 2.Gingival Index (G.I) (Loe and Sillness,1963) 3.Probing Pocket Depth (PPD) 4.Clinical Attachment Level (CAL)Timepoint: 1) At baseline 2) After 1 month 3) After 3 months 4) After 6 months

Secondary

MeasureTime frame
The radiographic bone fill will be evaluated using Intraoral Periapical Radiographs of the surgical siteTimepoint: 1) At Baseline 2) After 1 month 3) After 3 months 4) After 6 months

Countries

India

Contacts

Public ContactDr Mala Dixit Baburaj

Nair Hospital Dental College

maladixit25@gmail.com9223340938

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026