Comparative Evaluation of Bolus Esmolol and Fentanyl for Attenuation of Hemodynamic Pressor Response During Laryngoscopy and Endotracheal Intubation in Adult Patients Undergoing Elective Surgeries Under General Anaesthesia

comparitive evaluation of bolus administration of esmolol and fentanyl for pressor response attenuation during laryngoscopy and endotracheal intubation under general anaesthesia in elective surgeries - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112116

Enrollment

Registered

2026-06-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Intravenous Esmolol Bolus Intervention 2 milligrams per kg Intravenous Fentanyl Bolus Intervention 2microgram per kg: Group E (Esmolol Group) * Drug: Esmolol * Dose: 1.5 mg/kg intraven

Eligibility

Inclusion criteria

Inclusion criteria: Patients posted for elective surgeries under general anaesthesia requiring endotracheal intubation Patients belonging to American Society of Anesthesiologists ASAphysical status I and II Patients willing to participate and provide written informed consent Patients with anticipated normal airway and planned direct laryngoscopy

Exclusion criteria

Exclusion criteria: Patients with known hypersensitivity or contraindication to Esmolol Fentanyl Patients with significant cardiovascular diseases such as Ischemic heart disease Arrhythmias Heart block Congestive cardiac failure Severe hypertension Patients with bradycardia (heart rate less than 60 beat per minutes Patients with bronchial asthma or chronic obstructive pulmonary disease where beta blockers may be contraindicated Pregnant or lactating women

Design outcomes

Primary

Measure	Time frame
To compare the effectiveness of intravenous bolus Esmolol and Fentanyl in attenuation of hemodynamic pressor response to laryngoscopy and endotracheal intubation under general anaesthesia as assessed by changes in heart rate and blood pressure parameters systolic blood pressure diastolic blood pressure and mean arterial pressureat predefined time intervalsTimepoint: T0 Baseline: Before administration of study drug T1 Post-drug administration: 2 minutes after administration of study drug and immediately before laryngoscopy T2 During laryngoscopy T3 Immediately after endotracheal intubation T4 1 minute after intubation T5 3 minutes after intubation T6 5 minutes after intubation T7 10 minutes after intubation	—

Measure

Time frame

To compare the effectiveness of intravenous bolus Esmolol and Fentanyl in attenuation of hemodynamic pressor response to laryngoscopy and endotracheal intubation under general anaesthesia as assessed by changes in heart rate and blood pressure parameters systolic blood pressure diastolic blood pressure and mean arterial pressureat predefined time intervalsTimepoint: T0 Baseline: Before administration of study drug T1 Post-drug administration: 2 minutes after administration of study drug and immediately before laryngoscopy T2 During laryngoscopy T3 Immediately after endotracheal intubation T4 1 minute after intubation T5 3 minutes after intubation T6 5 minutes after intubation T7 10 minutes after intubation

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Secondary

Measure	Time frame
Incidence of adverse drug reactions Rate pressure product changes following intubation Requirement of rescue medications Peri intubation hemodynamic stability Incidence of perioperative complicationsTimepoint: Baseline Pre induction After administration of study drug Immediately after laryngoscopy and endotracheal intubation 1 minute after intubation 3 minutes after intubation 5 minutes after intubation 10 minutes after intubation Intraoperative period until completion of surgery Immediate postoperative period Post anaesthesia care unit	—

Measure

Time frame

Incidence of adverse drug reactions Rate pressure product changes following intubation Requirement of rescue medications Peri intubation hemodynamic stability Incidence of perioperative complicationsTimepoint: Baseline Pre induction After administration of study drug Immediately after laryngoscopy and endotracheal intubation 1 minute after intubation 3 minutes after intubation 5 minutes after intubation 10 minutes after intubation Intraoperative period until completion of surgery Immediate postoperative period Post anaesthesia care unit

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Countries

India

Contacts

Public ContactParvathareddy sri sai jaswanth

Vinayaka Missions Kirupananda Variyar Medical College and Hospitals

sabapathyv.appavoo@gmail.com9442566989

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026