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Study to check how a 1% concentrated antidiabetic medicine gel helps in dental implants healing and become stable in the jawbone

Evaluation of efficacy of 1 percent metformin gel on osseointegration around dental implants placed with surgical guide by using cone beam computed tomography and resonance frequency analysis: a randomized, single-blind controlled clinical trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112015
Enrollment
20
Registered
2026-06-05
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: drug: 1% metformin gel containing 1 gm metformin HCL powder and 1 ml gel coated on implant surface Control Intervention1: NIL: NIL Control Intervention2: placebo: not applicable

Sponsors

Indian society of periodontology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically Healthy patients Subjects with tooth missing in mandibular molar and premolar region Adequate interocclusal clearance Adequate mesiodistal space in edentulous area Patient reluctant for RPD and FPD Adequate mouth opening

Exclusion criteria

Exclusion criteria: History of smoking in past one year Compromised healing conditions i.e. uncontrolled diabetes mellitus, HIV infections, radiation therapy Bone disorders ( bone disease, hyperparathyroidism, osteoporosis, Paget s disease ) Patient with dental history of bruxism & parafunctional habits Pregnant and lactating women Patient under anticoagulant therapy

Design outcomes

Primary

MeasureTime frame
1.enhancement of osseointegration 2. primary implant stability achieved around dental implantsTimepoint: Baseline, 4th month

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Ravikumar Jirali

Vasantdada Patil dental college and hospital

ravijirali@gmail.com9980530913

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026