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A Study of Changes in Pain Sensitivity and Sleep Problems During Different Phases of the Menstrual Cycle in Women with Episodic Migraine

Menstrual Cycle-Related Variations in Central Sensitization and Sleep Dysregulation in Women with Episodic Migraine: A Physiotherapy Perspective. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/112004
Enrollment
32
Registered
2026-06-04
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G438- Other migraine

Interventions

Intervention1: Nil: Nil

Sponsors

Uttar Pradesh University of Medical Sciences Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Women aged between 18-49 years (according to WHO criteria for reproductive age). 2. Diagnosed with Episodic Migraine according to ICHD-3. 3. Regular menstrual cycles (24-38 days). 4. Written informed consent obtained prior to participation.

Exclusion criteria

Exclusion criteria: 1. Chronic migraine (more than 15 headache days per month). 2. Pregnancy or menopause. 3. Use of hormonal therapy or hormonal contraceptives. 4. Cognitive impairment or psychiatric disorders impairing ability to consent or follow instructions. 5. Neurological disorders other than migraine and diagnosed sleep disorders. 6. Use of medications affecting sleep patterns or central nervous system.

Design outcomes

Primary

MeasureTime frame
1.Outcome Central Sensitization Central Sensitization Inventory (CSI) a 25 item self report questionnaire assessing pain sensitivity, fatigue, sleep disturbance, and emotional distress. Total score (0 to 100) 2. Outcome Sleep Quality Outcome Variable Change in sleep quality Pittsburgh Sleep Quality Index (PSQI) Evaluates subjective sleep quality over the previous month across seven components. Total score (0 to 21)Self administered questionnaire. Timepoint: (T0) Ovulatory phase assessment (Day 12-16 of the menstrual cycle) and (T1) Perimenstrual phase assessment (day -2 to +3 of menstrual phase)—

Secondary

MeasureTime frame
Migraine Disability Assessment Scale (MIDAS) Measures disability due to migraine and its impact on daily activities and productivity over the previous three months. Total MIDAS score grade I to IV Method of Assessment: Self-administered questionnaire.Timepoint: 3 MONTHS—

Countries

India

Contacts

Public ContactDr Manisha Mishra

Uttar Pradesh University of Medical Sciences

physioneha04@gmail.com6395822600

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026