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A study comparing two ways to manage pain during liver removal surgery: a local nerve block with a specific sedative versus injecting morphine into the spinal fluid.

A Comparative study of External oblique intercostal plane block with dexmedetomidine versus Intrathecal morphine on acute post operative pain with a long term follow up of one year in open Donor Hepatectomy: A randomized control trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/111988
Enrollment
98
Registered
2026-06-04
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: external oblique intercostal block with dexmedetomidine: Ultrasound guided EOI Block will be given using in-plane approach an 18 G Tuohy needle will be inserted in cranial caudal dire

Sponsors

Institute of Liver and Biliary Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: undergoing open live donor hepatectomy

Exclusion criteria

Exclusion criteria: Patient refusal Contraindication to neuraxial anesthesia Allergy to local anesthetics Allergy to morphine Insufficient comprehension to use of PCA

Design outcomes

Primary

MeasureTime frame
compare the fentanyl consumption between the two groupsTimepoint: 24 hours

Secondary

MeasureTime frame
Difference in incidence of shoulder painTimepoint: nil;time of first rescue analgesiaTimepoint: nil;To assess chronic pain.Timepoint: 1st, 3rd, 6th and at 1 year;To compare the fentanyl consumption at 48 hours and 72 hours between the two groupsTimepoint: 48 hr and 72 hr;To compare the postoperative NRS( resting and dynamic)Timepoint: 0 hr (extubation), 2hr, 6hr,12hr, 24hr,36hr, 48hr and 72 hr;to compare acute pain stress biomarkers in both the groupsTimepoint: preoperatively just before induction of anesthesia(T0), 1 hr postoperatively(T1) and 24 hr postoperatively(T24);Monitoring of Heart rate, Systolic BP, Diastolic BP, Mean arterial pressure and Saturation both intra and postoperativelyTimepoint: Intra operatively- every hour Post operatively-0 hr (extubation),1hr, 2hr, 3hr,4hr,5hr, 6hr,12hr, 24hr,36hr, 48hr and 72 hr;To compare QoR 15 patient surveyTimepoint: 24 hour, 48h and 72 h;Monitoring Modified Ramsay score postoperativelyTimepoint: 0 hr (extubation), 2hr, 6hr,12hr, 24hr,36hr, 48hr and 72 hr;Difference total intraop fentanyl consumptionTimepoint: nil;Difference total intraop fluid consumptionTimepoint: nil

Countries

India

Contacts

Public ContactDr Gaurav Sindwani

Institute of Liver and Biliary Sciences

drsindwani25@gmail.com8728089898

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026