Health Condition 1: I672- Cerebral atherosclerosis
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Sponsors
Datta Meghe Institute of Higher Education And Research
Eligibility
Inclusion criteria
Inclusion criteria: 1.Adult patients (age more than 18 years) of either sex 2.Clinical diagnosis of acute ischemic stroke in last 30 days confirmed by neuroimaging (CT or MRI brain) 3.Symptom onset within 7 days of presentation 4.Neuroimaging (Computed Tomography Angiography or Magnetic Resonance Angiography) demonstrating 50 to 99 percent stenosis of a major intracranial artery (Intracranial Internal Carotid Artery, M1 segment of Middle Cerebral Artery, Intracranial Vertebral Arteries or Basilar Artery). 5.Symptomatic qualifying stenosis (i.e., located in the arterial territory corresponding to the clinical symptoms and infarct). 6.Ability of the patient or their legally authorized representative to provide written informed consent. 7.Ability to comply with follow-up visits (either in-person or via telephonic contact)
Exclusion criteria
Exclusion criteria: 1.Hemorrhagic stroke (intracerebral hemorrhage, subarachnoid hemorrhage) 2.Stroke secondary to venous sinus thrombosis 3.Stroke due to non-atherosclerotic vasculopathy (vasculitis, moyamoya disease, arterial dissection, fibromuscular dysplasia) 4.Previous endovascular (stenting, angioplasty) or surgical (bypass) treatment of the qualifying artery. 5.Patients with contraindications to CT angiography or MR angiography (severe renal dysfunction with eGFR more than 30 ml per min per 1.73 meter square, contrast allergy, claustrophobia, metallic implants for MRI) 6.Patients with concurrent life-threatening illness (advanced malignancy, end-stage organ failure) with life expectancy less than 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrent ischemic stroke within 3 months, defined as new focal neurological deficit of presumed vascular origin lasting more than 24 hours, occurring more than 24 hours after index stroke, with neuroimaging confirmation of new infarctTimepoint: At admission,Day 7,1 month and 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Any stroke (ischemic or hemorrhagic) at 3 months Functional outcome: mRS at 3 months (Good outcome: mRS 0-2; Poor outcome: mRS 3-6) Mortality at 3 months Combined vascular events (stroke, MI, vascular death) Timepoint: At admission,Day 7,1 month & 3 months | — |
Countries
India
Contacts
Public ContactDr Tushar Patil
Datta Meghe Institute Of Higher Education
Outcome results
None listed