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A study of Endosialin (TEM1/CD248), a tumor-associated marker, and its role in the diagnosis and prediction of outcomes in patients with colorectal cancer.

STUDY OF ENDOSIALIN (TEM 1 )/CD248 FOR ITS DIAGNOSTIC AND PROGNOSTIC CORRELATION IN PATIENT OF CANCER COLORECTUM - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/111902
Enrollment
40
Registered
2026-06-04
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C189- Malignant neoplasm of colon, unspecified

Interventions

Intervention1: Nil: Nil

Sponsors

Dr Suverna Jain
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1-Patients with a histopathological diagnosis of colorectal carcinoma on biopsy. 2-Patients with colorectal carcinoma who have undergone surgical resection and whose resected specimens are available for evaluation. 3-Patients with histologically confirmed adenocarcinoma of the colorectum, irrespective of tumor grade. 4-Patients with adequate clinical and pathological data available for analysis

Exclusion criteria

Exclusion criteria: The patient histopathologically diagnosis of cancer of cancer colorectum other than adenocarcinoma The patient having inadequate clinical details pertaining to histopathological diagnosis. The patient having inadequate tumor tissue block which are inadequate to be processed for immunostaining for endosialin/CD248/TEM1.

Design outcomes

Primary

MeasureTime frame
Assesment of Endosialin (TEM1/CD248( EXPRESSION IN ADENOCARCINOMA AND ITS CORRELATION WITH CLINICOPATHOLOGICAL PROGNOSTIC PARAMETER.Timepoint: At the time of histopathological examination of the biopsy and/or surgical resection specimen.—

Secondary

MeasureTime frame
### Secondary Outcomes 1. To evaluate the pattern & intensity of Endosialin (CD248/TEM1) expression in colorectal adenocarcinoma tissues by immunohistochemistry. 2. To determine the association between CD248 expression & histopathological parameters such as tumor grade, lymphovascular invasion, tumor stage, nodal stage, & TNM stage. 3. To assess the role of Endosialin as a potential marker of tumor angiogenesis in colorectal cancer. 4. To generate baseline Indian data regarding CD248/TEM1 expression in colorectal adenocarcinoma for future research & targeted therapy studies. Timepoint: At the time of histopathological examination & immunohistochemical analysis of the biopsy and/or surgical resection specimen, & during data analysis.—

Countries

India

Contacts

Public ContactSUVERNA JAIN

Datta Meghe Institute of Higher Education and Research.

DR.SUVERNAJAIN@GMAIL.COM7697736006

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026