Study to evaluate the effects of ketamine-propofol combination versus etomidate for anaesthesia induction on hemodynamic parameters in patient undergoing coronary artery bypass grafting surgery

A randomized comparative study to evaluate the effects of ketamine-propofol combination versus etomidate for anaesthesia induction on hemodynamic parameters in patient undergoing coronary artery bypass grafting surgery - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/111895

Enrollment

132

Registered

2026-06-04

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery

Interventions

Intervention1: Ketamine-propofol combination (1:1, 5mg/ml each) until loss of verbal response: To assess and compare haemodynamic parameters like Heart rate (HR) , Systolic Arterial Pressure (SAP), Di

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for elective coronary artery bypass surgery requiring anaesthesia induction with provided written informed consent belonging to American Society of Anaesthesiologist physical Status II or III aged 18-70 years

Exclusion criteria

Exclusion criteria: Known history of adrenal insufficiency. Steroid therapy within the preceding six months. Left ventricular ejection fraction (LVEF) less than 40%. Renal or hepatic insufficiency. Known allergies to study drugs. Use of propofol, ketamine, or etomidate within one week before surgery.

Design outcomes

Primary

Measure	Time frame
To assess and compare haemodynamic parameters like Heart rate (HR) , Systolic Arterial Pressure (SAP), Diastolic Arterial Pressure (DAP) , Mean Arterial Pressure (MAP), Central Venous Pressure (CVP) ,Cardiac Output (CO) ,Cardiac Index (CI) and Systemic Vascular Resistance (SVR) between two groups.Timepoint: 1-Baseline (T0) 2-After Induction (T1) 3-One minute post-intubation (T2) 4-Two Minute post induction (T3) 5-Three minutes post-intubation(T4) 6-Five minutes post-intubation(T5) 7-Ten Minutes post-intubation(T6)	—

Measure

Time frame

To assess and compare haemodynamic parameters like Heart rate (HR) , Systolic Arterial Pressure (SAP), Diastolic Arterial Pressure (DAP) , Mean Arterial Pressure (MAP), Central Venous Pressure (CVP) ,Cardiac Output (CO) ,Cardiac Index (CI) and Systemic Vascular Resistance (SVR) between two groups.Timepoint: 1-Baseline (T0) 2-After Induction (T1) 3-One minute post-intubation (T2) 4-Two Minute post induction (T3) 5-Three minutes post-intubation(T4) 6-Five minutes post-intubation(T5) 7-Ten Minutes post-intubation(T6)

—

Secondary

Measure	Time frame
1. To assess and compare serum cortisol levels and blood sugar levels between two groups 2. To assess and compare side effects if any between two groups Timepoint: 1- Baseline 2- After coming of bypass 3- After 24 hours of surgery	—

Countries

India

Contacts

Public ContactDr Marut Arora

SMS Medical College and Attached Hospitals Jaipur

dranjumsaiyed@gmail.com9214021930

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026