Health Condition 1: G620- Drug-induced polyneuropathy
Conditions
Interventions
Intervention1: Structured Exercise Program. The intervention will be provided for 3 sessions per week, for a duration of 8 weeks.: 1. Aerobic training given for 3 sessions per week, for a duration of
Sponsors
Amity University
Metro Heart Institute with Multispeciality
Eligibility
Inclusion criteria
Inclusion criteria: 1. Finished chemotherapy and is in clinical remission. 2. 6 to 24 months post chemotherapy 3. Peripheral neuropathy clinically proved to be caused by chemotherapy. 4. Neuropathy Partial or generalized length dependent, distal symmetric sensory motor peripheral polyneuropathy, with or without upper limb involvement, characterized mostly by lower limbs. 5. The severity of the neuropathy will consist of mild and moderate NCI CTCAE Grade 1 or 2. 6. Healthy, medically fit and allowed to engage in monitored physical activity by the treating oncologist. 7. Capacity to make an informed consent.
Exclusion criteria
Exclusion criteria: 1. Active malignancy or persistent chemotherapy. 2. Severe neuropathy NCI CTCAE Grade greater than 3. Non chemotherapy etiology of pre-existing peripheral neuropathy. 4. Marked heart, respiratory or neuromuscular disorders against exercise. 5. Compliance impaired by cognitive impairment. 6. Enrollment in trials of concurrent interventional rehabilitation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropathy severity measured using NCI CTCAETimepoint: Baseline at week 0 Post intervention at the end of week 12 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Inflammatory Biomarkers 2. Neuroplasticity Biomarker 3. Nerve Conduction Studies 4. Berg Balance Scale 5. Timed up and Go test 6. 6 minute walk testTimepoint: Baseline at week 0 Post intervention at the end of week 12 | — |
Countries
India
Contacts
Public ContactNidhi Sharma
Amity Institute of Health Allied Sciences, Amity University
Outcome results
None listed