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Comparison of Dehydroepiandrosterone Sulfate (DHEA-S) and Insulin-like Growth Factor 1 (IGF-1) levels in saliva with Skeletal Maturity Indicator in Orthodontic Patients

Assessment of Salivary Dehydroepiandrosterone Sulfate (DHEA-S) and Insulin-like Growth Factor 1 (IGF-1) levels in different Cervical Vertebral Maturation (CVM) Stages as Indicators of Skeletal Maturity in Orthodontic Patients - DHEA-S and IGF-1

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/111830
Enrollment
66
Registered
2026-06-03
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M264- Malocclusion, unspecified

Interventions

Intervention1: Nil: Nil

Sponsors

University College of Medical Sciences, Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Good periodontal health and no radiographic evidence of periodontal bone loss

Exclusion criteria

Exclusion criteria: 1. Craniofacial anomalies. 2. Systemic, endocrine, bleeding or adrenal disorders. 3. History of trauma or surgery in the region of cervical vertebrae 4. Pregnancy, lactation or medications affecting growth, hormones, or bone metabolism (including bisphosphonates and antiepileptic drugs). 5. Smokers or alcohol use. 6. Chronic steroid use, inhalers, or topical corticosteroids. 7. Active periodontal disease or oral infection.

Design outcomes

Primary

MeasureTime frame
1. Salivary levels of DHEA-S in different CVM stages. 2. Correlation between salivary DHEA-S levels and CVM stages.Timepoint: Baseline—

Secondary

MeasureTime frame
1. Salivary levels of IGF-1 in different CVM stages. 2. Correlation between salivary IGF-1 levels & CVM stages. 3. Correlation between salivary DHEA-S & IGF-1 levels.Timepoint: Baseline—

Countries

India

Contacts

Public ContactDr Mohd Nadeem

University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi

hgrewal@ucms.ac.in9818441899

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026