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Study of Vitamin D supplementation on Bone Health and Immune Function in Stable Kidney Transplant Recipients

Effect of Vitamin D Supplementation on Bone Health and Immune Repertoire in Kidney Transplant Recipient with Stable Kidney Function - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/111789
Enrollment
35
Registered
2026-06-03
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N185- Chronic kidney disease, stage 5

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Vitamin D Supplementation: Cap Cholecalciferol 600000 IU weekly once for 12 weeks. To repeat Serum 25(OH)D level at 12 weeks. If 25(OH)D

Sponsors

Arindam Mandal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age more than and equals to 18 years. 2. Kidney Transplant Recipients 5 year post-transplantation. 3. Serum creatinine less than 1.3 mg/dl 4. Serum 25(OH)D level less than 30 ng/ml

Exclusion criteria

Exclusion criteria: 1. Age less than 18 years 2.History of rejection in last 5 years 3. Basic kidney Disease is Diabetic Kidney Disease 4.HIV Positivity 5. Pretransplant use of immunosuppressive medications 6. Basic Kidney Disease is relapsing remitting in nature 7. Pregnancy or Breastfeeding

Design outcomes

Primary

MeasureTime frame
1. To look for impact of Vitamin D supplementation on Bone mineral density in DEXA scan. 2. To examine any improvement of bone biomarkers after Vitamin D supplementationTimepoint: 1. To look for impact of Vitamin D supplementation on Bone mineral density in DEXA scan. 2. To examine any improvement of bone biomarkers after Vitamin D supplementation—

Secondary

MeasureTime frame
1. Impact of Vitamin D supplementation in immune repertoire in participants. 2. To look for whether Vitamin D supplementation will shift the balance of immune microenvironment from proinflammatory niche to more immune tolerant niche.Timepoint: At baseline we will measure Regulatory T cells & at 6 month of Vitamin D supplementation we measure the same to look for any shift in Regulatory T cell population.—

Countries

India

Contacts

Public ContactDr Raja Ramachandran

Postgraduate Institute of Medical Education and Research, Chandigarh

drraja1980@gmail.com9216958874

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026