Health Condition 1: K228- Other specified diseases of esophagus
Conditions
Interventions
Intervention1: Modified CROSS PROTOCOL: Modified CROSS protocol (RT dose of 50.4Gy / 28fractions) with concurrent Chemotherapy
followed by surgery in locally advanced Oesophageal carcinoma, duration-
Sponsors
Mounika Sirimalla
Eligibility
Inclusion criteria
Inclusion criteria: 1.Biopsy proven oesophageal cancer. 2.Patients who did not receive any prior treatment for malignancy like surgery, radiotherapy, or chemotherapy. 3.Patients having malignancy in upper thoracic mid thoracic and lower thoracic oesophagus 4.Patients with malignancy of aforementioned sites of Stage II,III,IVa 5.Patients performance status should be less than or equal to 2 according to ECOG. 6.Patients who are able to give written consent.
Exclusion criteria
Exclusion criteria: 1.Patients having malignancy of cervical oesophagus 2.Patients with metastatic carcinoma 3.Patients who received prior treatment in the form of surgery, radiation, or chemotherapy 4.ECOG score more than 2 5.Patients with metastatic disease 6.Patients with deranged renal function 7.Patients not willing to give written consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the complete pathological response rates in both the armsTimepoint: 3months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the disease-free survival rates on the last follow up in each arm of the study. 2. To assess and compare toxicities as well as compliance in both the arms.Timepoint: 1year | — |
Countries
India
Contacts
Public ContactRohit Mahajan
All indian institute of medical sciences
Outcome results
None listed