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Comparison of two block for postoperative analgesia in laparoscopic surgery

Comparison of ultrasound-guided modified thoracoabdominal Nerve block through perichondrial approach and external oblique and Rectus abdominis plane blocks for postoperative analgesia and Perioperative stress biomarkers in laparoscopic cholecystectomy : a Randomized controlled trial - Nil

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/111730
Enrollment
66
Registered
2026-06-02
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group A: M-TAPA Group B: EXORA: All patients will receive standardized general anaesthesia. Depending on group allocation, patients in Group A will receive bilateral ultrasound-guided

Sponsors

Government Institute of Sciences(GIMS) Greater Noida
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status of I to III scheduled for elective laparoscopic cholecystectomy with BMI 18 to 30kg per meter Squuare.

Exclusion criteria

Exclusion criteria: 1.Infection at the injection site or systemic sepsis. 2.Known allergy to local anaesthetics such as bupivacaine. 3.Coagulopathy or anticoagulation therapy. 4.Chronic pain or pre-existing opioid tolerance. 5.Specific to Biomarkers History of endocrine disorders such as Cushing, Addison, or Diabetes Mellitus or use of steroids, as these significantly interfere with glucose levels.

Design outcomes

Primary

MeasureTime frame
Pain Intensity: NRS from 0 (no pain) to 10 (worst pain).Timepoint: Measurements are taken at rest and during movement (coughing) at specific intervals: 2, 4, 6, 12, and 24 hours postoperatively.—

Secondary

MeasureTime frame
Stress Biomarkers: 1.NLR: Measured via venous blood samples at T0 (baseline, pre-induction), T1 (6 hours postoperatively), and T2 (24 hours postoperatively). 2.Blood Glucose: Collected at the same time points. 3.PLR: Collected at the same time points. Analgesic Consumption: Total 24-hour tramadol consumption Side Effects: Monitoring PONV, pruritus, shoulder pain or respiratory depression. Timepoint: Stress Biomarkers: 1.NLR: Measured via venous blood samples at T0 (baseline, pre-induction), T1 (6 hours postoperatively), and T2 (24 hours postoperatively). 2.Blood Glucose: Collected at the same time points. 3.PLR: Collected at the same time points. Analgesic Consumption: Total 24-hour tramadol consumption Side Effects: Monitoring PONV, pruritus, shoulder pain or respiratory depression.—

Countries

India

Contacts

Public ContactDr Nazia Nazir

Government Institute of Medical Sciences(GIMS)

ssajr123@yahoo.com7023397398

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026