A study to compare healing, pain and swelling after partial lower wisdom tooth removal with and without local application of doxycycline 100mg and dexamethasone 4 mg in patients with impacted lower wisdom teeth.

Evaluation of the effect of coronectomy versus coronectomy along with local application of doxycycline 100mg and dexamethasone 4mg in impacted mandibular third molar- a Randomized Controlled Study. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/111654

Enrollment

Registered

2026-06-01

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Doxycycline 100mg and Dexamethasone 4mg: Patients allocated to the intervention group will undergo coronectomy of impacted mandibular third molars under local anesthesia using a standar

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged between 18 and 35 years. Impacted mandibular third molars requiring surgical removal. Patients with no deleterious oral habits like smoking, tobacco chewing. ASA Grade 1 patients. Patients willing to provide written informed consent and comply with follow-up.

Exclusion criteria

Exclusion criteria: Medically compromised or immunocompromised patients. Orthodontic extractions. Patients with temporomandibular joint disorders. ASA Grade 2 or higher patients. Patients with developmental or premalignant lesions associated with the 3rd molar. Patients unwilling or unable to return for follow-up.

Design outcomes

Primary

Measure	Time frame
The local application of doxycycline (100 mg) and dexamethasone (4 mg) following coronectomy of impacted mandibular third molars is expected to result in improved postoperative outcomes compared to conventional coronectomy alone, including reduced pain, swelling, and postoperative complications, along with enhanced soft tissue healing.Timepoint: Baseline, Day 3, Day 7, Day 14, Day 30, day 90	—

Secondary

Measure	Time frame
The intervention is also anticipated to improve periodontal healing, preserve sensitivity, and promote better radiographic bone formation distal to the adjacent mandibular second molar.Timepoint: Baseline, Day 3, Day 7, Day 14, Day 30, day 90	—

Countries

India

Contacts

Public ContactDR ABHILASHA YADAV

Government dental College and Hospital, Mumbai

drabhilasha@yahoo.com9890002523

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026