Health Condition 1: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems
Conditions
Interventions
Intervention1: Nasal Oscillometry with House Dust Mite (HDM) Nasal Provocation Testing in Patients with Allergic Rhinitis: Participants will undergo baseline nasal oscillometry using the Tremoflo C-1
Sponsors
Sir Ganga Ram Hoapital
Eligibility
Inclusion criteria
Inclusion criteria: Participants aged 12 years and above of either sex will be eligible for enrollment. The Allergic Rhinitis (AR) group will include adolescents and adults with a clinical diagnosis of allergic rhinitis characterized by typical symptoms such as sneezing, rhinorrhea, nasal obstruction, and or nasal itching, with a Visual Analogue Scale (VAS) score greather than or equal to 30 and documented sensitization to house dust mite (HDM) demonstrated by either a positive skin prick test (wheal diameter greater than or equal to 3 mm above negative control) or serum specific IgE positivity. The healthy control group will comprise age- and sex-matched individuals without a history of allergic rhinitis, asthma, or other atopic diseases and with negative HDM sensitization testing.
Exclusion criteria
Exclusion criteria: Participants will be excluded if they have uncontrolled asthma; active upper or lower respiratory tract infection; structural abnormalities of the nose, nasopharynx, or upper airway; history of tracheal stenosis, laryngeal disorders, tracheal surgery, recent nasal trauma, or nasal surgery; previous episodes of angioedema or choking; known anaphylaxis to house dust mite; pregnancy or lactation; recent systemic corticosteroid use (more than 10 mg/day within the preceding 2 weeks); vaccination within the previous 7 days or planned within 24 hours after testing; or inability/unwillingness to comply with study procedures and follow-up requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal airway resistance (oscillometric resistance values at predefined frequencies).Timepoint: Baseline assessment at enrollment before intervention (nasal provocation test), expected within a single study visit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in nasal airway resistance following House Dust Mite (HDM) nasal provocation test as measured by oscillometry and correlation with VAS and TNSS scores.Timepoint: 10 minutes after HDM nasal provocation test. | — |
Countries
India
Contacts
Public ContactNeeraj Gupta
Sir Ganga Ram Hospital
Outcome results
None listed