Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Chemotherapy: Patients who have undergone neoadjuvant chemotherapy lasting at least 12 weeks with the last dose falling within 2 months before surgery, shall receive a neuromuscular blo
Sponsors
Dr Shagun Bhatia Shah
Eligibility
Inclusion criteria
Inclusion criteria: ASA I-111 40-85 kg Post Neoadjuvant chemotherapy (taxanes: paclitaxel/docetaxel, anthracyclines: Adriamycin/epirubicin, and cyclophosphamide) Modified radical mastectomy
Exclusion criteria
Exclusion criteria: No consent Neuromuscular diseases (Myasthenia gravis, Duchenne muscular dystrophy, Guillain-Barre syndrome) Drugs affecting neuromuscular conduction (Aminoglycosides, tetracyclines, anticonvulsants)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time taken for 100 percent suppression of single second twitch post neuromuscular blocking agent injection Timepoint: Measured at the time of disappearance of single second twitches on peripheral nerve stimulation 1 minute after injection of neuromuscular blocking agent | — |
Secondary
| Measure | Time frame |
|---|---|
| Amount of neuromuscular blocking agent required to facilitate endotracheal intubation Timepoint: Measured 1 minute after endotracheal intubation;Time for appearance of the first response to post-tetanic count (PTC) stimulation Timepoint: Measured at 3 minutes, 4 minutes, 5 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes, & 30 minutes after endotracheal intubation.;Time for appearance of the first response to train-of-four stimulation Timepoint: Measured at 5 minutes, 6 minutes, 7 minutes, 8 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes, 30 minutes, 35 minutes, 40 minutes & 45 minutes after endotracheal intubation | — |
Countries
India
Contacts
Public ContactDr Shagun Bhatia Shah
Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi
Outcome results
None listed