To compare the drugs Pregabalin and tramadol with respect to pain control when given 60minutes before surgery to the patients undergoing total abdominal hysterectomy i.e removal of uterus per abdomen under spinal anaesthesia.

Comparative evaluation of the efficiency of tramadol and Pregabalin for perioperative analgesia in total abdominal hysterectomy under spinal anaesthesia. - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/111493

Enrollment

Registered

2026-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N858- Other specified noninflammatory disorders of uterus

Interventions

Intervention1: Tablet Pregabalin 75mg: The patient is given tablet Pregabalin 75mg orally 60minutes prior to the surgery. The pre-operative demography profile, baseline blood pressure and heart rate w

Eligibility

Inclusion criteria

Inclusion criteria: The patients who are scheduled for elective total abdominal hysterectomy under spinal anaesthesia . ASA physical status I or II Age 18 to 65 years Body mass index (BMI) of 18 to 35 kg/cm2

Exclusion criteria

Exclusion criteria: Patient refusal to participate in the study Contraindications to spinal anesthesia, Failed spinal anesthesia Known allergy to tramadol or pregabalin; Renal or hepatic dysfunction History of chronic pain or taking analgesics or anticonvulsants preoperatively or substance abuse Psychiatric illness or inability to understand pain scoring etc. History of Epilepsy

Design outcomes

Primary

Measure	Time frame
Postoperative pain assessment using Visual Analogue Scale score. Time of first dose of rescue analgesia. Total number of doses of rescue analgesia in 24 hours.Timepoint: Time points will be postoperatively 0 hours,1hour,2hour,3hour,4hour,5hour, 6hour,at 12hours and then at 24hours.	—

Secondary

Measure	Time frame
To compare incidence of common side effects like nausea, vomiting, shivering , sedation, sleep quality , dizziness, respiratory depression, pruritus and transient blurring of vision. Timepoint: 24months	—

Countries

India

Contacts

Public ContactDr Nandita Joshi

Dr Baba Saheb Ambedkar Medical College and Hospital Rohini Delhi

nandita2511@gmail.com9811927328

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026