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Role of Cyclosporine A eyedrops in Moderate to Severe Vernal Keratoconjunctivitis

Comparative Evaluation of 0.09 percent Cyclosporine A as an Adjuvant to Topical Steroids in the Management of Moderate to Severe Vernal Keratoconjunctivitis - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/111462
Enrollment
60
Registered
2026-05-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H104- Chronic conjunctivitis

Interventions

Intervention1: 0.09 percent cyclosporine A drops with topical corticosteroids: 0.09 percent cyclosporine A to be given twice a day with topical corticosteroids like Loteprednol four times a day Contro

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Clinical diagnosis of moderate to severe VKC (per Bonini grading) Active symptoms with at least two signs (limbal papillae, Trantas dots, corneal involvement)

Exclusion criteria

Exclusion criteria: Ocular infection or trauma Use of immunomodulatory drugs in the past 3 months History of glaucoma, cataract, or prior ocular surgery Known hypersensitivity to cyclosporine or study medications

Design outcomes

Primary

MeasureTime frame
Change in Total Symptom and Sign Score (TSSS) from baseline to Week 12Timepoint: baseline and week 12—

Secondary

MeasureTime frame
Reduction in total steroid doseTimepoint: week 12;Time to symptom resolutionTimepoint: earliest time to healing;Recurrence rate during the study periodTimepoint: time of recurrence (in weeks);Change in intraocular pressure (IOP)Timepoint: baseline and week 12;Adverse events (ocular discomfort, redness, IOP elevation)Timepoint: time of event—

Countries

India

Contacts

Public ContactDr Namrata Sharma

AIIMS

namrata.sharma@gmail.com01126593144

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026