A study comparing how three inhaled medicines affect heart rate, blood pressure, and oxygen levels during insertion of a breathing tube in patients undergoing gallbladder removal surgery.

Comparision of hemodynamic changes in response to laryngoscopy and tracheal intubation in patients nebulised with Ropivacaine(0.75%) vs dexmedetomidine vs Magnesium sulphate undergoing laproscopic cholecystectomy. - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/111451

Enrollment

Registered

2026-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: Nebulisation: Nebulisation with Ropivacaine(0.75%) Control Intervention1: Nebulisation: Nebulisation with dexmedetomidine Control Intervention2: Nebulisatiuon: Nebuloisation with Magne

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing laproscopic cholecystectomy falling under ASA1 and ASA2. Patients giving consent.

Exclusion criteria

Exclusion criteria: Patient with a history of sore throat or upper respiratory tract infection. Emergency patients. Patient with a history of allergy to local anaesthetics, dexmedetomidine,magnesium sulfate and ropivacaine. Patient requiring more than one attempt at intubation

Design outcomes

Primary

Measure	Time frame
The primary aim of study is to compare the hemodynamic response (Heart rate , Blood Pressusre , mean arterial pressure )in patients nebulised with ropivacaine 0.75% with nebulised dexmedetomidine( 1 microgram/kg) and with magnesium sulfate(40mg/kg) during intubation undergoing laparoscopic cholecystectomy under general anaesthesia.Timepoint: 6 hours,12 hours, 24 hours and 48 hours after surgery	—

Secondary

Measure	Time frame
To compoare the cough response at the time of extubation & incidence rate of postoperative sore throat. Timepoint: 6 hours,12 hours, 24 hours & 48 hours after surgery.;To access any adverse effects associated with nebulisation of Ropivacaine, dexmedetomidine & magnesium sulfate. Timepoint: 6 hours,12 hours, 24 hours & 48 hours after surgery.	—

Countries

India

Contacts

Public ContactShivam Satyarthee

Indra Gandhi Medical College, Shimla

drmkpanwar@gmail.com9418086876

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026