Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Intravenous Dexmedetomidine
( 1 microgram/kg ) made into 50ml Normal saline given over 10 minutes , 10 minutes before induction: Comparison of cardiovascular stress response while lar
Sponsors
Parul Institute of Medical Science and Research
Eligibility
Inclusion criteria
Inclusion criteria: Patients belonging to ASA 1 and 2 Patients undergoing elective surgery under general anaesthesia requiring endotracheal intubation No known history of drug allergy and sensitivity or other from of reaction to drugs used during anaesthesia Patients who provide informed written consent to participate in the study
Exclusion criteria
Exclusion criteria: Patients with known hypersensitivity or contraindications to Dexmedetomidine or Magnesium Sulfate Patients with significant cardiovascular diseases such as uncontrolled hypertension, arrhythmias, ischemic heart disease or failure Patients with renal or hepatic impairment Patients on medications that may interact with Dexmedetomidine or Magnesium Sulfate ( like calcium channel blockers, beta blockers) Pregnant and lactating women Patients with difficult airway anticipated or history of difficult intubation Emergency surgeries or patients requiring rapid sequence induction Patients with morbidly obesity ( Body Mass Index more than 30kilogram/meter square )
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Following parameters are measured to observe hemodynamic stability Heart rate Systolic blood pressure Diastolic blood pressure Mean arterial pressure SpO2 At before induction before intubation start of intubation 3 minutes after intubation 5 minutes after intubation 10 minutes after intubation 15 minutes after intubation Complications Timepoint: Following parameters are measured to observe hemodynamic stability Heart rate Systolic blood pressure Diastolic blood pressure Mean arterial pressure SpO2 At before induction before intubation start of intubation 3 minutes after intubation 5 minutes after intubation 10 minutes after intubation 15 minutes after intubation Complications | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr Galchar Payal Parbatbhai
Parul Institute of Medical Science and Research
Outcome results
None listed