Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Study group (Sublingual Buprenorphine): Study group will receive sublingual Buprenorphine 4.5 mcg per kg, 30 minutes prior to surgery and intravenous normal saline (0.9 percent) 10 ml,
Sponsors
Geetanjali medical college and hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18-60 years 2. ASA physical status I-II 3. Female patients posted for elective laparoscopic gynecological surgeries under GA
Exclusion criteria
Exclusion criteria: 1. Patients refusal for study 2. Patient with known hypersensitivity to the study drugs. 3. Patient with Anticipated difficult airway 4. BMI more than 30 kg per m2 5. Patient with severe cardiorespiratory, Hepatorenal diseases 6. Patient with History of regular use of opiates, pain medication, antidepressants, and anti-epileptic therapy. 7. Pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate and compare the efficacy of sublingual buprenorphine and intravenous nalbuphine for hemodynamic responses (Heart rate, Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure) during laryngoscopy, intubation, and pneumoperitoneum.Timepoint: During laryngoscopy, intubation then at 1,3,5,10,15 minutes after intubation as well as at start of pneumoperitoneum then every 5 minutes till 2o minutes after pneumoperitonium then after every 10 minutes interval till the deflation of carbon dioxide (CO2) and also at the time of extubation and 5,10 minutes thereafter till patient is shifted from post anaesthesia ward. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. VAS scores at various intervals and time to the first rescue analgesia. 2. Sedation by Ramsay sedation scale. 3. Adverse effects like nausea and vomiting, shivering, giddiness, headache, sweating, dry mouth.Timepoint: Postoperative 0,2,4,6,8 hours | — |
Countries
India
Contacts
Public ContactDr Anubha Jat
Geetanjali medical college and hospital
Outcome results
None listed