Health Condition 1: Z758- Other problems related to medicalfacilities and other health care
Conditions
Interventions
Intervention1: Collection and evaluation of salivary biomarkers in OSMF: Participants diagnosed with Oral Submucous Fibrosis will receive standard treatment according to clinical stage, including anti
Sponsors
Prin . K M Kundani College of Pharmacy
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged between 18 and 65 years. Individuals with a history of deleterious oral habits. Patients with clinically diagnosed cases of Oral Submucous Fibrosis of all grades. Patients classified as ASA I and ASA II will be included. Patients willing to participate in the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: Patients with Scleroderma, amyloidosis, Iron deficiency Anaemia, lesions superimposing OSMF and those disease altering the levels of salivary biomarkers. Patients with trismus due to disease other than OSMF. History of prior surgical treatment, radiotherapy and chemotherapy for OSMF or Cancer. Pregnant or lactating women. Patients on iron supplements. Patients on corticosteroid therapy. Patients belonging to ASA III and ASA IV classification. Patients with history of trauma. Patients with TMJ disorders. Patients unwilling to provide consent or comply with follow-up protocols.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment and comparison of salivary biomarker levels among OSMF patients, habit-associated individuals without OSMF, and healthy controlsTimepoint: For OSMF Patients- Baseline and 1 month post treatment. For habit associated - baseline For healthy controls - baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of salivary biomarker levels with clinical staging/severity of OSMF Association between duration/frequency of deleterious habits & salivary biomarker levels Comparison of biomarker levels between habit-associated individuals & healthy controls Evaluation of salivary biomarkers as potential indicators of disease progressionTimepoint: For osmf - baseline & one month post treatment For habit associated individuals - baseline For healthy individuals - baseline | — |
Countries
India
Contacts
Public ContactDr Urvi Gohil
Government Dental College , Mumbai
Outcome results
None listed