Comparing dexmedetomidine versus lignocaine inhalation Intervention Patients will receive inhalation either of the two drugs before intubation during surgery Outcome To find out which one is more effective in reducing the stress response

Comparative efficacy of preoperative nebulization dexmedetomidine and lignocaine on stress response prior to laryngoscopy and intubation: A Randomized Controlled Trial - DEXLIG

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/111333

Enrollment

100

Registered

2026-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: At dose of 1 mcg/kg diluted in normal saline to make total volume of 5ml given via nebulization for 10 minutes preoperatively Control Intervention1: Lignocaine: 2% at d

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA Grade 1 and 2 Patients scheduled for surgeries under general anesthesia 2.Informed Consent Provided

Exclusion criteria

Exclusion criteria: 1.ASA Grade 3 and 4 Patients 2.Allergy to above drugs 3.Severe Cardiopulmonary Illness

Design outcomes

Primary

Measure	Time frame
To compare the attenuation of the hemodynamic response(Heart rate and Blood Pressure) following preoperative nebulization of Dexmedetomidine and LignocaineTimepoint: Baseline outcomes compared between both groups preoperatively (pre nebulization), Post nebulization,Pre Intubation, Immediately after Intubation, at 1st, 3rd, 5th and 10th minute post nebulization	—

Secondary

Measure	Time frame
To compare Electrocardiographic changes between the two groups receiving nebulization of Dexmedetomidine and LignocaineTimepoint: Baseline outcomes intraoperatively;To compare sedation scores after receiving nebulization of Dexmedetomidine and LignocaineTimepoint: Outcomes compared between both groups intraoperatively and postoperatively;To compare adverse effects and patient outcomes during the intraoperative and postoperative period following nebulization of Dexmedetomidine and LignocaineTimepoint: Outcomes compared between 2 groups preoperatively, intraoperatively and postoperatively	—

Measure

Time frame

To compare Electrocardiographic changes between the two groups receiving nebulization of Dexmedetomidine and LignocaineTimepoint: Baseline outcomes intraoperatively;To compare sedation scores after receiving nebulization of Dexmedetomidine and LignocaineTimepoint: Outcomes compared between both groups intraoperatively and postoperatively;To compare adverse effects and patient outcomes during the intraoperative and postoperative period following nebulization of Dexmedetomidine and LignocaineTimepoint: Outcomes compared between 2 groups preoperatively, intraoperatively and postoperatively

—

Countries

India

Contacts

Public ContactDr Swetapadma Mishra

Heritage Institute of Medical Sciences

aryanindia2003@yahoo.com8888832639

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026