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To compare two routes of dexmedetomidine (intravenous versus intranasal) in terms of blood loss during functional endoscopic nasal sinus surgery in patients under General Anaesthesia.

A randomized double blind comparative study between intravenous versus intranasal dripping of dexmedetomidine on intraoperative blood loss during functional endoscopic nasal sinus surgery under General Anaesthesia at SMS Medical College, Jaipur - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/111256
Enrollment
68
Registered
2026-05-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous dexmedetomidine before (1mcg/kg) and during (0.5mcg/kg/hr) FESS: Group 1 will be infused with intravenous dexmedetomidine ( 1mcg/kg) in 100 ml of Normal Saline (0.9%) over 1

Sponsors

Department of Anaesthesia Sawai Man Singh Medical College Jaipur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing FESS surgery under general anaesthesia. 2. Patients willing to give informed written consent. 3. Patient weight between 60-80kgs. 4. Patients come under American Society of Anaesthesiologists (ASA) physical status 1 to 3

Exclusion criteria

Exclusion criteria: 1. Patients with hypertension, pregnant females, neuromuscular illnesses (myopathies and myasthenia gravis), hematological diseases. 2. Patients with psychiatric conditions, use of analgesics or sedatives within 24 hours before surgery, known heart conditions , calcium channel blocker users. 3. Patients having drug allergy to dexmedetomidine.

Design outcomes

Primary

MeasureTime frame
To assess and compare between intravenous and intranasal dripping administration of dexmedetomidine on intraoperative blood loss during functional endoscopic nasal sinus surgery by Boezaart s grading scale in patients under general anaesthesia.Timepoint: 1. Time of starting point of surgery is 0 minutes. 2. Then we will measure the amount of blood loss in surgical field every 15 minutes according to Boezaart s grading scale.—

Secondary

MeasureTime frame
1. To compare hemodynamic stability ( Heart Rate, Mean arterial pressure) between two groups. 2. To measure surgical satisfaction by using 5- point Likert scale. 3. To evaluate the sedation by using Ramsey Sedation Score. 4. To observe and record post op adverse effects such as Bradycardia, Hypotension and Desaturation, 5. To evaluate recovery profile.Timepoint: 5 minutes, 10 minutes , 15 minutes—

Countries

India

Contacts

Public ContactDr Sonali Beniwal

SMS Medical College Jaipur

drsonalisms@gmail.com9214540552

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026