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Comparison of Eggshell-Based Bone Graft and Donor Bone Graft for Healing Bone Defects in Gum Disease Patients

Comparitive evaluation of eggshell derived nano hydroxyapatite versus demineralized freeze dried bone allograft (DFDBA) in the treatment of periodontal intrabony defects A randomized controlled clinical trail - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/111237
Enrollment
15
Registered
2026-05-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis Health Condition 2: K053- Chronic periodontitis Health Condition 3: K053- Chronic periodontitis

Interventions

Intervention1: Egg shell derived nano hydroxyapatite: Egg shell derived nano hydroxyapatite bone graft is placed in the inrabony defects Control Intervention1: Demineralized freeze dried bone allograf

Sponsors

Dr Arunkumar Dodamani
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Participants aged 18 years or older with at least one periodontal intrabony defect involving a two-wall or three-wall defect were included in the study. The selected teeth were required to be vital or have undergone successful endodontic treatment. Defects associated with probing pocket depth of 5 mm or more were considered eligible. Subjects were required to maintain a plaque score of less than 1 and should not have undergone any previous surgical procedure at the intended treatment site. Only systemically healthy individuals were included in the study.

Exclusion criteria

Exclusion criteria: Teeth exhibiting poor prognosis with Grade 2 or Grade 3 mobility were excluded from the study. Teeth with furcation involvement greater than Grade 2 were also excluded. Subjects who had undergone periodontal surgery in the area of interest within the previous two years were not considered for inclusion. Pregnant and lactating women, as well as individuals with a habit of tobacco use in either smoked or smokeless form, were excluded. Subjects with systemic conditions that contraindicated periodontal surgery were also excluded from the study.

Design outcomes

Primary

MeasureTime frame
Eggshell-derived nano-hydroxyapatite (EnHA) is expected to demonstrate superior regenerative potential and greater radiographic bone fill when compared to demineralized freeze-dried bone allograft (DFDBA). This study will further help in evaluating and characterizing the biological behavior and regenerative efficiency of EnHA, thereby supporting its potential use as an effective bone graft substitute in periodontal regeneration.Timepoint: 6 months

Secondary

MeasureTime frame
Eggshell-derived nano-hydroxyapatite (EnHA) demonstrates superior cost-effectiveness and greater ease of availability when compared to demineralized freeze-dried bone allograft (DFDBA), making it a practical alternative for regenerative procedures. Its favorable economic and logistical profile enhances its feasibility for widespread use in routine clinical practice and supports its adoption as a reliable graft material for periodontal regeneration.Timepoint: 6 months

Countries

India

Contacts

Public ContactDr Arunkumar Dodamani

Government Dental College, Raipur

shirishtirkey@gmail.com9399093749

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026