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Effect of Simvastatin on bone healing after wisdom tooth removal

Efficacy of Simvastatin in Bone Regeneration following local application in third molar extraction socket A Randomised split mouth study - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/111206
Enrollment
40
Registered
2026-05-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Simvastatin powder Gelfoam moistened with saline: Patient third molar extraction will be performed under local anesthesia, and site will be prepared for placement of Simvastatin 10mg p

Sponsors

sardar patel post graduate institute of dental and medical sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with bilaterally impacted mandibular third molars with similar class, position and angulation. 1. Patients between 18 -50 years of age of both genders 2.Patients who fall within the ASA 1 (American Society of Anaesthesiology) classification 3. Patient without any other systemic diseases or comorbidities.

Exclusion criteria

Exclusion criteria: Patients with poor oral hygiene. 1. Pregnant or lactating women. 2. Patients who declined participation. 3. Presence of systemic illness.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare postoperative bone density between Simvastatin-treated sockets and control sockets in mandibular third molar extraction sockets.Timepoint: Estimated till 4 Months

Secondary

MeasureTime frame
To evaluate & compare pain & swelling associated with local application of Simvastatin in mandibular third molar extraction sockets.Timepoint: Estimated till 1 week

Countries

India

Contacts

Public ContactDr Madan Mishra

Sardar Patel Post Graduate Institute Of Dental And Medical Sciences

mm.15mds@gmail.com9565740127

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026