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A study comparing 2 different intubation techniques(A procedure done for airway management & mechanical ventilation) in patients with physiologically difficult Airway.

Comparing efficacy of Rapid sequence intubation and Delayed sequence intubation in anticipated physiologically difficult airway in adult patients presenting to Emergency Room: A Randomised Controlled Trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/111193
Enrollment
120
Registered
2026-05-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems

Interventions

Intervention1: Delayed Sequence Intubation: 1.Preoxygenation achieved using ketamine sedation while maintaining spontaneous breathing. 2.After reaching optimal oxygenation (SpO2 93%), neuromuscular b

Sponsors

All India Institute of Medical Sciences(AIIMS)-Nagpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adults(more than or equal to 18y age) requiring emergent intubation. 2.DAPS(Difficult physiological airway score) more than or equal to five. 3.No immediate need for establishing surgical airway.

Exclusion criteria

Exclusion criteria: 1.Cardiac arrest prior to intubation. 2.Patient on NIV prior to intubation. 3.Do-Not-Intubate (DNI) status. 4.Patients with conditions contraindicating the use of ketamine (e.g., increased intracranial pressure, acute angle-closure glaucoma) or contraindicating neuromuscular blocking agents. 5.Pregnant patients.

Design outcomes

Primary

MeasureTime frame
To compare the incidence of Peri Intubation Hypoxia(PIH) defined by 1.SpO2 below 93% at any point of time after pre-oxygenation till 10 minutes after Endotracheal intubation(ETI),if it was above 93% at end of pre-oxygenation or 2.fall in SpO2 by beyond 10% at any point of time after pre-oxygenation till 10 minutes after ETI,if it was below 93% at the end of pre-oxygenation or 3.Critical desaturation i.e., below 70% at any point of time after Pre-oxygenation till 10 minutes after ETI.Timepoint: At any point of time from Pre-oxygenation till 10 minutes after placement of ETT.—

Secondary

MeasureTime frame
To compare Incidence of Post-intubation hypotension within 60min Timepoint: 60min;To compare Incidence of Post-intubation cardiac arrest within 60minTimepoint: 60min;To compare First pass intubation success rateTimepoint: -NA-;To compare No of intubation attemptsTimepoint: -NA-;To compare Duration of procedure(Time for NMBA administration to successful placement of tube)Timepoint: -NA-;To compare Need for rescue ventilation during the procedure. Timepoint: -NA-;To compare Need for the use of alternative techniques among both groups i.e., subjects undergoing RSI compared with subjects undergoing DSI.Timepoint: -NA-—

Countries

India

Contacts

Public ContactDr Gadamsetty Poorna Sandeep

All India Institute of Medical Sciences(AIIMS)-Nagpur

ajay@aiimsnagpur.edu.in9562627879,9995025217

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026