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Effect of Mouthwashes on Germs Causing Tooth Decay

Comparative Evaluation of Antimicrobial Efficacy of Punica granatum-meswak,Punica granatum-Grape Fruit and Chlorhexidine Mouth rinses against streptococcus mutans:A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/111166
Enrollment
28
Registered
2026-05-26
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K02- Dental caries Health Condition 2: B95- Streptococcus, Staphylococcus, andEnterococcus as the cause of diseases classified elsewhere

Interventions

Intervention1: punica granatum Meswak mouthrinse: 10 mL mouthrins used once daily for 60 seconds for 30 days Intervention2: punica granatum grapefruit mouthrinse: 10 mL mouthrinse used once daily for

Sponsors

SRM Kattankulathur Dental College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children aged 8-15 years with moderate,high or very high DMFT scores,without relevant medical history or orthodontic appliances and whose parents/guardians provide consent for participation.

Exclusion criteria

Exclusion criteria: Children with low or very low DMFT scores Children with systemic/medical ilnesss Children on medications or antibiotics within past 6 months Children with known allergy to mouthrinse components Children without parent/guardian consent

Design outcomes

Primary

MeasureTime frame
Reduction and comparison of Streptococccus mutans count in saliva after use of Punic granatum meswak,punica granatum Grapefruit and Chlorhexidine mouthrinses.Timepoint: Time point1- Baseline Time point2- 2 weeks Time point3- 1 month

Secondary

MeasureTime frame
Comparison of antimicrobial efficacy between herbal mouthrinses and chlorhexidine mouthrinse.Timepoint: Time point-1 month;Assessment of reduction in colony forming units (CFU/mL) of Streptococcus mutans.Timepoint: Time point- 2 weeks and 1 month

Countries

India

Contacts

Public ContactDr Arya Acca Varghese

SRM Kattankulathur Dental College and Hospital

aryaaccv@srmist.edu.in8556992698

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026