Health Condition 1: E70-E88- Metabolic disorders Health Condition 2: E02- Subclinical iodine-deficiency hypothyroidism
Conditions
Interventions
Intervention1: Levothyroxin: 1.5 mcg/kg/day orally,one time a day, for 12 weeks
Control Intervention1: NIL: NIL
Sponsors
Dr Barkha Choudhary
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18 to 60 years 2. Diagnosed with subclinical hypothyroidism (TSH 5 to 10 mIU perL, normal fT4) 3. Diagnosis of metabolic syndrome based on ATP III criteria (3 of the following) a. Waist circumference more than 102 cm (men) or more than 88 cm (women) b. Fasting triglycerides more than or equal to 150 mg perdL c. HDL C less than 40 mg perdL (men) or less than 50 mg perdL (women) d. Blood pressure more than or equal to 130 by 85 mmHg or on antihypertensives e. Fasting glucose more than or equal to 100 mg perdL
Exclusion criteria
Exclusion criteria: 1. Overt hypothyroidism or hyperthyroidism 2. Previous thyroid surgery or radioactive iodine therapy 3. Use of lipid lowering agents in the past 3 months 4. Pregnancy or lactation 5. Severe systemic illness or malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in pre and post LDL C level from baseline after 3 months 2. Changes in pre and post total cholesterol, HDL C, triglycerides from baseline after 3 monthsTimepoint: 3 months from the date of recruitment | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in pre and post TSH and fT4 from baseline after 3 monthsTimepoint: 3 months from the date of recruitment | — |
Countries
India
Contacts
Public ContactDr Barkha Choudhary
Maharaja Agrasen Medical College, Agroha
Outcome results
None listed