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Comparison of Dexmedetomidine and Esmolol in Reducing Blood Pressure and Heart Rate Changes During Intubation in Patients Undergoing Elective Surgery Under General Anesthesia

A Prospective Randomized Double-Blind Interventional Study to Evaluate the Effectiveness of Dexmedetomidine versus Esmolol in Attenuating Hemodynamic Response to Laryngoscopy and Endotracheal Intubation in Adult Patients Undergoing Elective Surgeries Under General Anesthesia - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/111100
Enrollment
88
Registered
2026-05-26
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K638- Other specified diseases of intestine

Interventions

Intervention1: Esmolol: iv esmolol 0.5 mg per kg in 20 mL NS iv slowly over 10 min Control Intervention1: Dexmedetomidine: iv dexmedetomidine 0.5mcg/kg in 20 mL normal saline iv slowly over 10 minutes

Sponsors

SMS MEDICAL COLLEGE AND HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient undergoing general surgery under general anesthesia. Patients willing to give written informed consent. Patients belonging to American Society of Anaesthesiologist (ASA) physical status grade I and II. Patients of either sex. Age Groups 20 to 80 years

Exclusion criteria

Exclusion criteria: Patients having history of convulsion and history of allergy to anaesthestic agents used in study. Patients having history of asthma, copd, thyrotoxicosis, hypothyroidism, on rate controlling drugs. Patients with anticipated difficult intubation i.e Mallampati class 3 or more, restricted neck movement or restricted mouth opening. Pregnant patients and lactating mothers

Design outcomes

Primary

MeasureTime frame
To determine and compare the heart rate at various time intervals in both the groups.Timepoint: Baseline Preinduction During intubation 1 min after intubation 3 min after intubation 5 min after intubation 10 min after intubation—

Secondary

MeasureTime frame
To assess and compare hemodynamic parameters like systolic blood pressure, diastolic blood pressure and mean arterial blood pressure at different time intervals in both the groups. To assess and compare hemodynamic parameters like rate pressure product at different time intervals in both the groups. Timepoint: Baseline Preinduction During intubation 1 min after intubation 3 min after intubation 5 min after intubation 10 min after intubation;To assess and compare the incidence of adverse effects (hypotension, bradycardia) between both the groups.Timepoint:—

Countries

India

Contacts

Public ContactDR SAVITA MEENA

SMS MEDICAL COLLEGE AND HOSPITAL

Cm.praveen012kumar@gmail.com8123735032

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026