Comparison of Various Painkillers in Third Molar Extractions

Analgesic Efficacy of Ibuprofen, Ketorolac, Mefenamic Acid and Tramadol in Third Molar Surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/111091

Enrollment

112

Registered

2026-05-26

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Ketorolac: Available as a dispersible tablet administered per orally. It is an acetic acid derivative type of Non Steroidal Anti Inflammatory Drug (NSAID) Dosage: 10 mg Frequency: 8 ho

Eligibility

Inclusion criteria

Inclusion criteria: Presence of impacted/partially erupted mandibular third molar requiring surgical removal

Exclusion criteria

Exclusion criteria: - Known hypersensitivity to NSAIDs - History of asthma, cardiac abnormalities, liver and kidney diseases - Patient under anti-platelet medications - Active peptic ulcer disease or bleeding disorder - Pregnancy or lactation - History of chronic analgesic use

Design outcomes

Primary

Measure	Time frame
Assessing pain score with the Numerical Rating ScaleTimepoint: 24, 48 and 72 hours	—

Secondary

Measure	Time frame
Correlation of pain with impaction difficultyTimepoint: 24 hour, 48 hours & 72 hours;Incidence of complications (swelling, trismus, alveolar osteitis, infection)Timepoint: At 1 week	—

Countries

India

Contacts

Public ContactEsha Verma

A B Shetty Memorial Institute of Dental Sciences

drpadmarajhegde@nitte.edu.in9845788987

Outcome results