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Comparative Evaluation of Advanced Cavity Disinfection Methods in Primary Teeth

Comparative evaluation of antimicrobial efficacy of phycocyanin loaded silver nanoparticles activated by diode laser, SDF and low-level laser as cavity disinfectants in primary molars: An In-vivo study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110986
Enrollment
80
Registered
2026-05-25
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Low-level laser irradiation: Low-level laser irradiation used as cavity disinfectant after caries excavation in primary molars prior to restoration for 5 cycles for 15 seconds with a pa

Sponsors

Dr Zarnab
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Single-surface occlusal cavities involving both enamel and dentin. 2.Lesion Size: Cavities wide enough to allow access for hand instruments. 3.Caries Activity: Active carious lesions without pulpal involvement. 4.Tooth Condition: Non-restored primary molars with no history of previous treatment in the affected tooth.

Exclusion criteria

Exclusion criteria: 1.Patients exhibiting radiographic evidence of irreversible pulpitis or pulp necrosis. 2.Patients with a history of pain associated with the teeth designated for treatment. 3.Teeth with severe structural damage, rendering them non-restorable. 4. Patients who have undergone antibiotic treatment within the past four weeks. 5. Patients with photosensitivity disorders (e.g., porphyria). 6. Patients on photosensitizing medications (e.g., tetracyclines, isotretinoin).

Design outcomes

Primary

MeasureTime frame
1)Microbiological assessment and comparison of the total viable bacterial count before and after application of SDF-KI, diode laser, PC-PDT and PC@AgNPs-PDT. 2)Microbiological assessment and comparison of streptococcus mutans count before and after application of SDF-KI, diode laser, PC-PDT and PC@AgNPs-PDT. 3)Microbiological assessment and comparison of lactobacilli count before and after application of SDF-KI, diode laser, PC-PDT and PC@AgNPs-PDT. Timepoint: Baseline 30 min—

Secondary

MeasureTime frame
1) Microbiological assessment & comparison of the total viable bacterial count before & after application of SDF-KI, diode laser, PC-PDT & PC@AgNPs-PDT. 2) Microbiological assessment & comparison of streptococcus mutans count before & after application of SDF-KI, diode laser, PC-PDT & PC@AgNPs-PDT. 3) Microbiological assessment & comparison of lactobacilli count before & after application of SDF-KI, diode laser, PC-PDT & PC@AgNPs-PDT. Timepoint: Baseline 30 minutes—

Countries

India

Contacts

Public ContactProf Dr Nazia Lone

GOVERNMENT DENTAL COLLEGE AND HOSPITAL SRINAGAR

lonenazia1@gmail.com9419060028

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026