To know the effect of Hyaluronic Acid with bone graft on periodontal defects in an intervention study in patients with chronic periodontitis, and compare with the patients receiving bone graft without hyaluronic acid by measuring radiographic and clinical parameters.

Assessment of the Effect of Hyaluronic Acid with Xenograft in the Treatment of Periodontal Infrabony Defects : A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110966

Enrollment

Registered

2026-05-22

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Hyaluronic Acid with Bone graft: After Surgical debridement of the Infrabony defect, it will be treated with hyaluronic acid containing Bovine Xenograft type of Bone graft which will be

Eligibility

Inclusion criteria

Inclusion criteria: Nearly bilateral symmetrical sites, defect with one tooth gap, Pocket probing depth of more than 6mm, Radiographic evidence of vertical bone defect of more than 3mm, systemically healthy patients

Exclusion criteria

Exclusion criteria: Medically compromised patients, patients on any antibiotics, anti-inflammatory drugs and on drugs affecting Bone healing in the last 6 months, Known allergy to any of the study materials, patients who have undergone surgical periodontal therapy in the last 6 months, smokers and tobacco users, pregnant or lactating females

Design outcomes

Primary

Measure	Time frame
Radiographic parameters- Defect width, defect depth and defect fill percentageTimepoint: Defect width and Defect depth measured at baseline and 6 months postoperatively Defect fill percentage will be measured at 6 months post operatively	—

Secondary

Measure	Time frame
Plaque index (PI), Gingival index (GI), Periodontal Probing Depth (PPD), Clinical Attachment Level (CAL), Modified Healing Index (MHI)Timepoint: Baseline, 3 months and 6 months post operatively	—

Countries

India

Contacts

Public ContactDr Rajesh Kumar Thakur

Uttar Pradesh University of Medical Sciences

dr.rkthakurperio@gmail.com9997060666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026