FindTrial
Sign In

A Study Comparing PRP Injection and Low-Level Laser Therapy Along with Exercise for Reducing Pain and Improving Function in People with Knee Osteoarthritis

Comparative Effectiveness of Platelet-Rich Plasma Injection versus Low-Level Laser Therapy Each Combined with a Standardised Exercise Programme in Knee Osteoarthritis: A Randomised Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110965
Enrollment
104
Registered
2026-05-22
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee

Interventions

Intervention1: Platelet-rich plasma: Participants will receive a single 3mL intra-articular injection of autologous PRP Control Intervention1: LASER: Patients will receive low-level laser therapy usin

Sponsors

R. G. Kar Medical College, Kolkata
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Knee pain for more tha 3 months, fulfilling American College of Rheumatology (ACR) clinical criteria for knee osteoarthritis. Radiographic Kellgren Lawrence Grade II osteoarthritis. VAS pain on movement more than or equal to 40 mm (on a 100-mm scale). Ability and willingness to perform the prescribed exercise programme and provide written informed consent.

Exclusion criteria

Exclusion criteria: Previous knee arthroplasty or major knee surgery within the past 12 months. Intra-articular corticosteroid or hyaluronic acid injection within the past 6 months. Secondary or inflammatory arthritis (e.g., rheumatoid arthritis, gout). Coagulopathy, platelet disorders, active infection, or malignancy. Neurological deficit in the lower limb. Pregnancy or lactation. Severe cognitive impairment. Participation in another interventional clinical trial within the past 3 months.

Design outcomes

Primary

MeasureTime frame
To compare changes in pain intensity (on movement and at rest) measured by Visual Analogue Scale (VAS) and the pain subscale of the Knee Injury and Osteoarthritis Outcome Score (KOOS) from baseline to 24 weeks between the PRP + exercise and LLLT + exercise groups.Timepoint: baseline (pre-treatment), 4 weeks, 8 weeks, and 12 weeks post-treatment—

Secondary

MeasureTime frame
To compare changes in other KOOS subscales (symptoms, activities of daily living, sports/recreation, quality of life).Timepoint: baseline (pre-treatment), 4 weeks, 8 weeks, and 12 weeks post-treatment;To assess changes in WOMAC score, 30-second chair-stand test, range of motion, and analgesic/NSAID consumption up to 24 weeks.Timepoint: baseline (pre-treatment), 4 weeks, 8 weeks, and 12 weeks post-treatment—

Countries

India

Contacts

Public ContactDr Pankaj Kumar Mandal

R. G. Kar Medical College and Hospital, Kolkata

rehabyouall@gmail.com9433915696

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026