Comparison of two pain-relief medicines (Nalbuphine and Butorphanol) given with Propofol anaesthesia in women undergoing early pregnancy uterine evacuation procedures

A comparative study between nalbuphine with propofol versus butorphanol with propofol for total intravenous anaesthesia in dilatation and evacuation surgery in a first trimester pregnancy - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110947

Enrollment

Registered

2026-05-22

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O074- Failed attempted termination of pregnancy without complication

Interventions

Intervention1: Group-N(Nalbuphine): Midazolam 0.03 mg/kg IV, Glycopyrrolate 0.2 mg IV, Nalbuphine 0.1mg/kg IV, Propofol 2 mg/kg IV. Control Intervention1: Group B(Butorphanol): Midazolam 0.03 mg/kg IV

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade II. First Trimester Mother. Hemodynamically stable patients.

Exclusion criteria

Exclusion criteria: BMI more than 35. Expected duration more than 20 minute. Hemodynamically unstable patient. History of drug abuse. History of allergy to the study drugs.

Design outcomes

Primary

Measure	Time frame
To assess post operative analgesiaTimepoint: upto 3hours after injecting the drugs	—

Secondary

Measure	Time frame
To compare hemodynamic parametersTimepoint: intra operative every 5 minutes , post operative every 10 minute;To compare recovery profiles including time to awakening and readiness to shift out from Operating room to PACUTimepoint: Post operatively;Comparison of decreasing of oxygen saturation below 92% with face mask oxygen & need of Bag Mask ventilation during surgeryTimepoint: intra operatively;To assess the incidence of perioperative adverse effects such as nausea, vomiting, HypotensionTimepoint: post operatively every 10 minutes;To compare the need of repeatation of dosage of Propofol during the procedureTimepoint: intraoperatively	—

Measure

Time frame

To compare hemodynamic parametersTimepoint: intra operative every 5 minutes , post operative every 10 minute;To compare recovery profiles including time to awakening and readiness to shift out from Operating room to PACUTimepoint: Post operatively;Comparison of decreasing of oxygen saturation below 92% with face mask oxygen & need of Bag Mask ventilation during surgeryTimepoint: intra operatively;To assess the incidence of perioperative adverse effects such as nausea, vomiting, HypotensionTimepoint: post operatively every 10 minutes;To compare the need of repeatation of dosage of Propofol during the procedureTimepoint: intraoperatively

—

Countries

India

Contacts

Public ContactMohammad Nadim Munna

Midnapore Medical College and Hospital

svk32maity@gmail.com9432938120

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026