Health Condition 1: I083- Combined rheumatic disorders of mitral, aortic and tricuspid valves Health Condition 2: I710- Dissection of aorta Health Condition 3: I255- Ischemic cardiomyopathy
Conditions
Interventions
Intervention1: Group A N-Acetylcysteine: Intravenous N-Acetylcysteine 1.2g BD will be administered 12 hours prior to surgery during the pre-operative period continued intraoperatively 2.4g IV at the i
Sponsors
Sri Ramachandra Institute of Higher Education And Research
Eligibility
Inclusion criteria
Inclusion criteria: Adult Patients, Inclusive Of Both Genders, Undergoing Cardiothoracic Surgery On Cardiopulmonary Bypass Between The Age Of 18 To 70
Exclusion criteria
Exclusion criteria: Age less than 18 years Renal and hepatic insufficiency Left ventricular ejection fraction (LVEF) less than 35 percent. H/O Hematological disorders Previous H/O Vitamin C or N-acetylcysteine (NAC) allergy Aortic cross clamp time of greater than 120 minutes Emergency cardiac surgeries Redo cardiothoracic surgery Inflammatory bowel disease Connective tissue disorder People on antioxidant therapy vitamin C, E, Selenium, Beta-carotene H/O of Steroid therapy or Anti-cancer therapy H/O GI bleeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of reactive oxygen species and oxidative stress markers following antioxidant therapy in patients undergoing cardiothoracic surgery on cardiopulmonary bypass.Timepoint: 8 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr T Periyasamy
Department of Cardiothoracic and Vascular Surgery.
Outcome results
None listed