Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: genotype guided analgesia
: Analgesia will be provided according to genotype for up to 48hours after surgery.
Control Intervention1: Control(Usual Care): Analgesic management per stan
Sponsors
DHR-MRU
Eligibility
Inclusion criteria
Inclusion criteria: ASA Grades one two and three Elective major abdominal surgery requiring postoperative opioid analgesia Postoperative hospital stay more than 48 hrs Written informed consent
Exclusion criteria
Exclusion criteria: Chronic opioid use for more than seven days preoperatively Severe hepatic or renal impairment Pregnancy or lactation Allergy to study drugs Declines genetic testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare total opioid consumption in the first 48 hours after surgery between the two groups.Timepoint: At 48 hours after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare postoperative pain scores (NRS) at rest & movement. To compare the incidence of opioid-related adverse events (respiratory depression, sedation, PONV) in 48 hours. Measure feasibility outcomes: proportion with actionable genotype, median lab turnaround time, proportion of patients in intervention arm where genotype altered prescription. Assess patient satisfaction with pain control (Likert scale) & hospital length of stay. Timepoint: at 6, 12, 24, 48h after Surgery | — |
Countries
India
Contacts
Public ContactUrvashi Yadav
UPUMS, Saifai,
Outcome results
None listed