None listed
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Community-dwelling or institutionalized older adults. 2. Edmonton Frail Scale score of 8 or higher (Screening tool). 3. Mild cognitive impairment- MoCA score of 18-25 (Screening tool). 4. Presence of stable, managed chronic conditions (e.g., diabetes, hypertension, thyroid) . 5. Adequate vision and hearing with or without aids permitted. 6. Access to digital technology and internet. 7. Able to read and understand English
Exclusion criteria
Exclusion criteria: 1. Participants with moderate to severe cognitive impairment (screened using Trail Making Test), dementia or Alzheimer s disease 2. Acute illness or infection at assessment 3. Use of anti-inflammatory or immunosuppressive medications (including corticosteroids or immunomodulators) 4. Currently engaged in structured exercise programs or very high physical activity ( more than 5 hours per week) 5. Severe psychiatric disorders (schizophrenia, bipolar disorder, severe depression) 6. Unstable vital signs (blood pressure, heart rate, respiratory rate, oxygen saturation) 7. History of trauma or surgery within the past 6 months 8. Bedbound status or severe mobility limitations with or without assistance 9. Current malignancy or undergoing chemotherapy or radiotherapy 10. History of seizures or major neurological disorders (such as Parkinson s disease or stroke) 11. Inability to understand study instructions due to language barriers will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Physical frailty by [Clinical frailty scale and Short Physical Performance Battery (SPPB)] 2. Cognitive frailty by [Montreal Cognitive Assessment (MoCA)] 3. Psychological frailty by [Tilburg Frailty Indicator (TFI)- Psychological frailty domain] 4. Social Frailty [Social Frailty Scale (SFS-8)]Timepoint: Baseline (before the start of intervention) On the last day of week 3 On the last day of week 6 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Inflammatory biomarkers of frailty by blood CRP levels. 2. Sleep quality by Pittsburgh Sleep Quality Index (PSQI) 3. Quality of life by Older People s Quality of Life (Brief)-OPQOL-BREF Timepoint: Baseline (before the start of intervention) On the last day of week 3 On the last day of week 6 | — |
Countries
India
Contacts
Delhi Pharmaceutical Science and Research University