Comparing three drugs for their beneficial effect on lung during operation on one lung

Comparison of effect of nebulized dexmedetomidine, intravenous dexmedetomidine and intravenous propofol infusions on intrapulmonary shunt, lung compliance, and oxygenation during OLV and lung injury post OLV - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110850

Enrollment

Registered

2026-05-21

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulized dexmedetomidine: 2 g/kg dexmedetomidine constituted to 5ml using 0.9% saline shall be nebulized over 10min just after intubation to maintain anaesthetic depth during one lun

Eligibility

Inclusion criteria

Inclusion criteria: Weighing 45-80kg Undergoing one lung ventilation

Exclusion criteria

Exclusion criteria: Non Consent, Bradyarrhythmias, Prolonged Q-T Interval, Propofol allergy, Deranged kidney function tests Deranged liver function tests

Design outcomes

Primary

Measure	Time frame
Partial pressure of oxygen in the arterial blood (PaO2)Timepoint: Measured at baseline (15 minutes post intubation during two lung ventilation), 30 min post initiation of one lung ventilation, 60 minutes post-initiation of one lung ventilation, and 15 minutes post resumption of two lung ventilation	—

Secondary

Measure	Time frame
Dynamic ComplianceTimepoint: Measured at baseline (15 minutes post intubation during two lung ventilation), 30 min post initiation of one lung ventilation, 60 minutes post-initiation of one lung ventilation, and 15 minutes post resumption of two lung ventilation;Shunt fractionTimepoint: Measured at baseline (15 minutes post intubation during two lung ventilation), 30 minutes post initiation of one lung ventilation, 60 minutes post-initiation of one lung ventilation, and 15 minutes post resumption of two lung ventilation;Postoperative pulmonary complicationsTimepoint: Measured at the end of 24 hours postoperatively;Length of surgical intensive unit stayTimepoint: Measured when the patient is shifted to the ward	—

Measure

Time frame

Dynamic ComplianceTimepoint: Measured at baseline (15 minutes post intubation during two lung ventilation), 30 min post initiation of one lung ventilation, 60 minutes post-initiation of one lung ventilation, and 15 minutes post resumption of two lung ventilation;Shunt fractionTimepoint: Measured at baseline (15 minutes post intubation during two lung ventilation), 30 minutes post initiation of one lung ventilation, 60 minutes post-initiation of one lung ventilation, and 15 minutes post resumption of two lung ventilation;Postoperative pulmonary complicationsTimepoint: Measured at the end of 24 hours postoperatively;Length of surgical intensive unit stayTimepoint: Measured when the patient is shifted to the ward

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Countries

India

Contacts

Public ContactDr Shagun Bhatia Shah

Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi

drshagun_2010@rediffmail.com09891769779

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026