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A New Use for Insulin: Healing Persistent Eye Surface Defects in Diabetics

A hospital based study tosses the efficacy of topical insulin drops as adjuvant therapy in diabetic Keratopathy - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110848
Enrollment
10
Registered
2026-05-21
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: Topical Insulin as adjutant: Dose16IU/Ml one drop four times daily till epithelial defect completely heals Control Intervention1: Standard therapy for non infective keratitis: Topical l

Sponsors

Sarojini Naidu Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with type 2 Diabetes Mellitus, maintained under adequate glycemic control, presenting with non-healing, non-infective corneal epithelial defects (negative microbiology reports for ulcer scrapings)

Exclusion criteria

Exclusion criteria: Patients who had recent ocular surgery, chemical injuries, severe dry eye, poor adherence to treatment, or active infectious keratitis were excluded

Design outcomes

Primary

MeasureTime frame
Primary outcome will be the time to complete healing of corneal epithelial defectTimepoint: first at baseline then after starting treatment Patient will be seen everyday during first week then three times weekly in the second week and weekly thereafter until complete epithelialization.—

Secondary

MeasureTime frame
visual improvement, complications, & additional surgical interventions. Timepoint: maximum time was 21 days—

Countries

India

Contacts

Public ContactShefali Mazumdar

Sarojini Naidu Medical College

dralps0209@gmail.com8527180540

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026