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A Clinical Study to Evaluate the Effectiveness and Safety of Nanoneedling With a Skin Tightening and Brightening Gel Compared to a Placebo Gel on Facial Skin

A Prospective, Randomized, Split-Face Study to Assess the Efficacy and Safety of nanoneedling Assisted Concentrated DMAE and MSM Application Versus Placebo Gel on Facial Skin Tightening and Skin Lightening - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110816
Enrollment
15
Registered
2026-05-21
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nano-needling with concentrated DMAE and MSM serum : One side receives nano- needling assissted application of a concentrated DMAE and MSM serum. Two treatment sessions, 2 weeks apart,

Sponsors

Silphion Research Private Limited
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Healthy male or female participants aged more than 18 years. Willingness to comply with study procedures Written informed consent

Exclusion criteria

Exclusion criteria: Active facial dermatoses or infections Facial procedures (lasers, peels, injectables) within past 2 months Use of topical retinoids or depigmenting agents within 4 weeks Pregnancy or lactation Known hypersensitivity to DMAE or gel components

Design outcomes

Primary

MeasureTime frame
Change in facial skin surface characteristics from baseline to Week 8, assessed using standardized Reveal imaging under controlled lighting conditions (standard and cross-polarized modes) with automated image processing and comparative analysisTimepoint: Week 4, Week 8—

Secondary

MeasureTime frame
Change in Skin Gloss Change in Skin Lightening index Assessment of Standardized Clinical Photography Assessment of erythema, irritation, edema, or any adverse events at each visitTimepoint: Week 4, Week 8—

Countries

India

Contacts

Public ContactDr Savitha Murali

RENDER SKIN AND HAIR

drsavitha@renderclinic.com6385519654

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026