Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Remifentanil: Remifentanil will be administered intravenously using a Target-Controlled Infusion (TCI) pump based on the Minto pharmacokinetic model. The infusion will be maintained at
Sponsors
Shree Krishna Hospital, Pramukh Swami Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Patents of age more than 18 yr. Patent scheduled for laparoscopy surgery under general anaesthesia. Patent who are able to provide written and informed consent Patent with ASA status I, II, III
Exclusion criteria
Exclusion criteria: Refusal to give written and informed consent Hemodynamically unstable patent (patents in shock or on vasopressor support) History of drug allergy/allergy to study drugs Pregnant and lactating patent Patents with ASA class IV or more Those scheduled for cancer surgery Those undergoing emergency surgery Those with chronic pain on medication Hypotension, Bradycardia, atrioventricular, intraventricular or Sinoatrial block
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamic parameters, including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), measured at baseline and at 15-minute intervals throughout the duration of surgery.Timepoint: Intraoperative hemodynamic parameters, including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), measured at baseline and at 15-minute intervals throughout the duration of surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time (end of surgery); postoperative pain (NRS) and sedation (RSS) at 0, 15, 30, 45, and 60 minutes in PACU; and incidence of adverse events (bradycardia, hypotension, nausea, vomiting, shivering) during intraoperative period and up to 60 minutes postoperatively.Timepoint: Extubation time at end of surgery; pain (NRS) and sedation (RSS) at 0, 15, 30, 45, and 60 minutes in PACU; adverse events recorded intraoperatively and up to 60 minutes postoperatively. | — |
Countries
India
Contacts
Public ContactDr Prashant Parmar
Shree Krishna Hospital, Karamsad
Outcome results
None listed