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Investigation of Pain Associated Molecular Alterations in Diabetic Neuropathy

Clinical investigation of peripheral sensitization in diabetic neuropathy focusing on NMDA receptor mediated molecular differences between painful and non-painful patients - nil

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/05/110807
Enrollment
280
Registered
2026-05-21
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil Intervention2: nil: nil

Sponsors

nil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with a confirmed diagnosis of Diabetes Mellitus (Type 1 or Type 2) based on medical records or physician diagnosis

Exclusion criteria

Exclusion criteria: Presence of autoimmune diseases associated with neuropathy

Design outcomes

Primary

MeasureTime frame
Comparison of NMDA receptor expression in peripheral nerve tissue between painful diabetic neuropathy (PDN) and non-painful diabetic neuropathy (NPDN) patients.Timepoint: single point sample collection, and there is no time point—

Secondary

MeasureTime frame
Plasma glutamate & glutamine levels in PDN & NPDN patients measured using HPLC.Timepoint: single point sample collection & there is no time point;Expression levels of glutamate transporters EAAT1 & EAAT2 in peripheral nerve tissue.Timepoint: single point sample collection & there is no time point—

Countries

India

Contacts

Public ContactMr Sudarshan Parameswaran

Sri Ramachandra Institute of Higher Education and Research

sudansudarshan001@gmail.com7338773181

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026