Health Condition 1: O- Medical and Surgical Health Condition 2: D430- Neoplasm of uncertain behavior ofbrain, supratentorial
Conditions
Interventions
Intervention1: Fentanyl pre-treatment 5 minutes before induction of anaesthesia: GROUP B (Pretreatment group) will receive fentanyl five minutes prior to induction of anaesthesia with propofol.
Contr
Sponsors
DR ANUSHA KAKARLA
Eligibility
Inclusion criteria
Inclusion criteria: ASA physical status grade I and II patients. Elective craniotomy and excision of a large supratentorial tumour (size of 4cm and above).
Exclusion criteria
Exclusion criteria: Patient drowsy (Glasgow coma score less than 15) Emergency surgery or repeat surgery ASA physical status grade III or more Allergy or contraindications to the study drugs Hepatic failure or renal insufficiency Cardiovascular abnormality and baseline hemodynamic instability Difficult airway (MP Grade III and IV) Patients at risk for aspiration of gastric contents Morbid obesity (BMI more than 40 kg/m2) Pregnant patients Significant midline shift (more than 10 mm) or signs of impending herniation requiring urgent intervention Use of preoperative sedatives or opioids or propofol within 24 hours History of opioid abuse Patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Induction dose of propofol (ml) in both groupsTimepoint: Induction of anaesthesia | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate (HR) and mean arterial pressure (MAP)Timepoint: baseline (before giving the first drug), after two minutes of giving the first drug, just before giving the second drug, immediately before intubation, then two and five minutes after endotracheal intubation;Need of esmolol, ephedrine, noradrenaline and atropine.Timepoint: From the administration of the first drug till 5 minutes after intubation.;Patient State Index (PSI) for depth of anaesthesiaTimepoint: Baseline (before giving the first drug), after two minutes of giving the first drug, just before giving the second drug, immediately before intubation, then two and five minutes after endotracheal intubation.;Bilateral regional cerebral oxygenation (rSO2) valuesTimepoint: Baseline (before giving the first drug), after two minutes of giving the first drug, just before giving the second drug, immediately before intubation, then two and five minutes after endotracheal intubation.;Oxygen saturation (SpO2) valuesTimepoint: Baseline (before giving the first drug), after two minutes of giving the first drug, just before giving the second drug, immediately before intubation, then two and five minutes after endotracheal intubation. | — |
Countries
India
Contacts
Public ContactDR MIHIR PRAKASH PANDIA
ALL INDIA INSTITUTE OF MEDICAL SCIENCES
Outcome results
None listed