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Comparison of Pain Relief Methods After Jaw Fracture Surgery Using Ketorolac, Paracetamol, and Their Combination.

Comparative evaluation among IV ketorolac, IV paracetamol and combination of IV ketorolac and IV paracetamol in postoperative pain control following open reduction and internal fixation of mandibular fractures under general anesthesia - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110792
Enrollment
75
Registered
2026-05-21
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M264- Malocclusion, unspecified

Interventions

Intervention1: IV Ketorolac: Intravenous Ketorolac 30 mg administered postoperatively in the post anesthesia care unit upon onset of pain. Intervention2: IV Paracetamol: Intravenous Paracetamol 1g adm

Sponsors

Eshita Jana
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Should be 18 -50 years of age 2. Patients of either gender undergoing open reduction and internal fixation (ORIF)for mandibular fractures under general anesthesia. 3. ASA I and ASA II patient. 4. Patients who provided written informed consent for participation in the study. 5. Patients willing to comply with postoperative monitoring and follow-up schedule.

Exclusion criteria

Exclusion criteria: 1. Any patient not fulfilling inclusion criteria . 2. History of hypersensitivity or allergy to NSAIDs, ketorolac, or paracetamol. 3. ASA III and ASA IV patients. 4. Patients receiving chronic analgesic or corticosteroid therapy. 5. Patients who required conversion to a different analgesic regimen intraoperatively or postoperatively due to complications. 6. Pathological fractures,malunited fractures, non-united fractures, and fractures older than three weeks 7. Fractures requiring autogenous bone grafts 8. Patients under any medications or therapy which may affect the outcome of results. 9. Patients with history of bowel obstruction or abnormal bowel movements .

Design outcomes

Primary

MeasureTime frame
To evaluate and compare postoperative pain intensity using VAS scores among patients receiving IV Ketorolac,IV Paracetamol and IV Ketorolac combined with IV Paracetamol following ORIF of mandibular fractures under general anaesthesiaTimepoint: Postoperative pain assessment at:30 mins,1 hour,2 hour,4 hour,6 hour,12 hours,24 hours—

Secondary

MeasureTime frame
Requirement of rescue analgesia. Time to first rescue analgesia. Hemodynamic changes. Adverse effects.Timepoint: Time to first rescue analgesia recorded within the first 24 hours postoperatively—

Countries

India

Contacts

Public ContactSubhransu Basu

Haldia Institute of Dental Sciences and Research

27eshitajana@gmail.com8617681449

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026