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A study in patients undergoing major abdominal surgeries to find the best dose of epidural ropivacaine with or without dexmedetomidine for effective postoperative pain relief.

To determine median effective concentration (EC50) and effective concentration 95%(EC95) in patients of ropivacaine with or without dexmedetomidine for post operative epidural analgesia in patients undergoing major abdominal surgeries:an up - down sequential allocation study. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/05/110694
Enrollment
60
Registered
2026-05-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K639- Disease of intestine, unspecified

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

Dr Prof Manoj Kumar Panwar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Scheduled for major abdominal surgeries including gynaecological surgeries. 2. ASA grade I TO III male and female. 3. Aged between 18 and 80 years. 4. Body mass index less than 35.

Exclusion criteria

Exclusion criteria: 1. Refusal to undergo epidural analgesia 2. Infection at the epidural insertion site 3. History of coagulopathy 4. Severe hypovolemia 5. Raised intracranial pressure (ICP) 6. Pre-existing neurological deficits or demyelinating disorders 7. Severe spinal deformity 8. Coexisting cardiorespiratory disease, such as ventricular dysfunction or a history of AV block/bradyarrhythmias 9. 10. Not extubated and transferred to the ICU postoperatively

Design outcomes

Primary

MeasureTime frame
Postoperative pain assessed using VASTimepoint: At 2 hours interval till 40 hours postoperative—

Secondary

MeasureTime frame
hypotension , bradycardia , motor blockade by checking vitals sign & using modified bromage scaleTimepoint: 2 hourly interval till 40 hours—

Countries

India

Contacts

Public ContactPradeep Kumar Sharma

IGMC Shimla

drmkp@gmail.com9418086876

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026