Health Condition 1: N171- Acute kidney failure with acute cortical necrosis
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: No intervention: No intervention
Sponsors
PV Sai Saran
Eligibility
Inclusion criteria
Inclusion criteria: 1.Critically ill adults aged 18 years and above 2.Non renal SOFA score more than 6 3.Acute Kidney Injury stage 2 or higher based on KDIGO criteria 4. Patients initiated on renal replacement therapy
Exclusion criteria
Exclusion criteria: 1.End stage renal disease on maintenance hemodialysis 2.Patients with pre-existing dysnatremia defined as Pre SLED serum Na less than 125 or more than 147mEq per L which are not compatible with the dialysate sodium protocol of study OR couldnt fit into existing dialysis machine 128 to 155 mEq per L 3. Ongoing therapies that substantially alter sodium balance such as hypertonic saline infusion 4. Pregnant patients 5. Chronic liver disease 6. Variations in SLED prescription such as Na and UF profiling other than constant pattern
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate and magnitude of serum sodium change in mEq per L per session in critically ill patients undergoing sustained low efficiency dialysis SLEDTimepoint: 15 minutes before SLED and 15 minutes after SLED | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hemodynamic instability related to renal replacement therapy HIRRT Dialysis adequacy measured by Kt V & urea reduction ratioTimepoint: Baseline, 15 minutes after initiation, 30 minutes, 1 hour after initiation,2 hours after initiation, 4hours after initiation Kt V & urea reduction ratio will be assesed before & after SLED. | — |
Countries
India
Contacts
Public ContactSai Saran
Sanjay gandhi postgraduate institute of medical sciences
Outcome results
None listed