Which neurostimulant Medicine Better Speeds Up Recovery After a Stroke Compared to Regular Therapy

A study to know the effectiveness of amantadine and modafinil in comparison with standard rehabilitation in acute stroke recovery, A prospective, single blind, randomised controlled study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110602

Enrollment

Registered

2026-05-19

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I639- Cerebral infarction, unspecified Health Condition 2: I629- Nontraumatic intracranial hemorrhage, unspecified

Interventions

Intervention1: Administration of Amantidine drug: Amantidine 100mg twice daily per oral or through ryles tube along with standard stroke rehabilitation for stroke patients for a period of 6 months Int

Eligibility

Inclusion criteria

Inclusion criteria: Diagnosed with acute ischemic/hemorrhagic stroke GCS between 8 and 13/ reduced responsiveness

Exclusion criteria

Exclusion criteria: Prior use of neurostimulants Active seizure disorder Severe hepatic or renal impairment History of psychiatric illness Pregnant or lactating women

Design outcomes

Primary

Measure	Time frame
1. Improvement in FIM (functional independence measure) 2. Improvement in SIS(stroke impact scale) 3. Improvement in MMSE( mini mental state examination) 4. Improvement in mRS(Modified Rankin Scale)Timepoint: Follow up will be done at 1 month, 3 months and 6 months	—

Secondary

Measure	Time frame
Duration of hospital stay across all three groupsTimepoint: Follow up will be done at 1 month, 3 months and 6 months	—

Countries

India

Contacts

Public ContactDr G Sambi Reddy

ESIC Medical College and Hospital

sambireddy57@yahoo.com9848260927

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026