A Study on Early Detection of Successful Arm Nerve Block Using Perfusion Index and Dexmedetomidine

Influence of perineural Dexmedetomidine on the diagnostic accuracy of perfusion index for predicting successful supraclavicular brachial plexus block: A Randomized double-blind study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/05/110574

Enrollment

Registered

2026-05-18

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Group dexmedetomidine: In the block area, baseline parameters will be noted 45 minutes before shifting the participant into the operating theatre. The pulse oximeter probe will be place

Eligibility

Inclusion criteria

Inclusion criteria: Age between 18 and 65 years ASA physical status I and II Surgeries for upper limb below the elbow

Exclusion criteria

Exclusion criteria: Patient refusal Absolute contraindications for the block Patients weighing less than 50kg BMI more than 30 kg/m2 Baseline heart rate less than 60 beats per min Patients on alpha or beta blockers Peripheral vascular disease Allergy to the study drugs

Design outcomes

Primary

Measure	Time frame
To compare the PI ratio at 10 minutes post blockTimepoint: 10 minutes post block	—

Secondary

Measure	Time frame
1. To compare the PI ratio at 1, 3, 5, 15 & 30 minutes post block 2. Comparing the AUC of PI ratio between groups at 1, 3, 5, 10, 15 & 30 minutes post-block using area under the ROC curve (AUC) 3. To determine the optimal PI ratio cut-off at 10 minutes for predicting successful block using ROC analysis 4. To assess additional PI kinetics - Time to significant PI ratio rise (1.5 times baseline) & Peak PI ratio values at predefined time points 5. To compare block characteristics between groups - Time to onset of sensory block & time to onset of motor block 6. To correlate the PI ratio at 10 minutes with clinical indicators of block success (sensory blockade) 7. To compare adverse events including bradycardia & hypotensionTimepoint: 1,3,5,10,15,30 minutes post block	—

Measure

Time frame

1. To compare the PI ratio at 1, 3, 5, 15 & 30 minutes post block 2. Comparing the AUC of PI ratio between groups at 1, 3, 5, 10, 15 & 30 minutes post-block using area under the ROC curve (AUC) 3. To determine the optimal PI ratio cut-off at 10 minutes for predicting successful block using ROC analysis 4. To assess additional PI kinetics - Time to significant PI ratio rise (1.5 times baseline) & Peak PI ratio values at predefined time points 5. To compare block characteristics between groups - Time to onset of sensory block & time to onset of motor block 6. To correlate the PI ratio at 10 minutes with clinical indicators of block success (sensory blockade) 7. To compare adverse events including bradycardia & hypotensionTimepoint: 1,3,5,10,15,30 minutes post block

—

Countries

India

Contacts

Public ContactArun Parthasarathy

Kasturba Medical College, Manipal

p.arun1991@gmail.com9600129686

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026